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In this study, alarin levels in the cord blood of babies with large birth weights will be compared with babies of normal weight. Thus, the investigators aimed to find out whether there is a relationship between babies' birth weights and alarin.
Studies have shown that the galanin neuropeptide family plays a role in regulating appetite, insulin resistance, obesity, hypertension and metabolism. Alarin is a peptide consisting of 25 amino acids. Current research shows that allerin plays an important role in the emergence and development of diabetes and obesity. There are studies that found that the serum alarin level increased significantly in patients with impaired glucose tolerance and type 2 diabetes mellitus. Additionally, studies have found that both non-obese and obese type 2 diabetes mellitus serum alarin levels increase.
Studies in the literature are related to adults, and there are no studies on alarin levels in newborn babies.
Based on the alarin studies available in the literature, the investigators determined whether there is a relationship between the alarin level and the baby's birth weight by comparing the alarin level in the cord blood of babies with a high birth weight according to their gestational age (both babies of diabetic mothers and babies of non-diabetic mothers) compared to babies whose birth weight is within the normal range. the investigators aimed to find it.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Appropriate for gestational age | Appropriate for gestational age |
| |
| small for gestational age | small for gestational age |
| |
| large for gestational age | large for gestational age |
| |
| Baby of mother diagnosed with GDM | Baby of mother diagnosed with gestational diabetes mellitus |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Appropriate for gestational age , small for gestational age, large for gestational age, Baby of mother diagnosed with GDM | Diagnostic Test | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of cord blood alarin levels of babies in different groups according to birth weight (low-appropriate-large) and babies of mothers diagnosed with gestational diabetes regardless of birth weight. | umbilical cord blood alarin levels | postnatal 5 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Babies born between the planned dates and whose families gave consent for the study were divided into four different groups according to their characteristics:
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| Name | Affiliation | Role |
|---|---|---|
| MELEK BUYUKEREN | Konya City Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MELEK | Konya | Sıhhiye | 06100 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33536771 | Result | Zhou X, Luo M, Zhou S, Cheng Z, Chen Z, Yu X. Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients. Diabetes Metab Syndr Obes. 2021 Jan 27;14:379-385. doi: 10.2147/DMSO.S290072. eCollection 2021. | |
| 31305464 | Result | Hu W, Fan X, Zhou B, Li L, Tian B, Fang X, Xu X, Liu H, Yang G, Liu Y. Circulating alarin concentrations are high in patients with type 2 diabetes and increased by glucagon-like peptide-1 receptor agonist treatment: An Consort-compliant study. Medicine (Baltimore). 2019 Jul;98(28):e16428. doi: 10.1097/MD.0000000000016428. |
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Study Protocol, Statistical Analysis Plan and Clinical Study Report
6 months after the article was published
The data set generated and analyzed in this study are available from corresponding author on a reasonable request.
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| ID | Term |
|---|---|
| D001724 | Birth Weight |
| ID | Term |
|---|---|
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D005865 | Gestational Age |
| ID | Term |
|---|---|
| D047109 | Fetal Development |
| D005314 | Embryonic and Fetal Development |
| D009024 | Morphogenesis |
| D048788 | Growth and Development |
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| D010829 |
| Physiological Phenomena |
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |