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Exploring the ED90 of remimazolam in Drug-induced Sleep Endoscopy in adults at different BMI groups.
Exploring the ED90 of remimazolam in Drug-induced Sleep Endoscopy in adults at different BMI groups, to provide a more scientific medication scheme for sedation in Drug-induced Sleep Endoscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal group | Experimental | BMI: ≥18.5 and <24 |
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| overweight group | Experimental | BMI: ≥24 and <30 |
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| obese group | Experimental | BMI: ≥30 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remimazolam | Drug | Exploring ED90 induced by remimazolam anesthesia in adults of different BMI groups undergoing drug-induced sleep endoscopy |
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| Measure | Description | Time Frame |
|---|---|---|
| Ramsey Sedation Scale | Using the Ramsey Sedation Scale scoring table ranging from 1-6 to evaluate if the sedation is successful 1point: Patients are anxious, restless or irritable; 2point: Patients cooperative, well-oriented and quiet; 3point: Patients fall asleep and respond only to commands; 4point: Patients fall asleep and respond quickly to eyebrow taps or loud auditory stimuli; 5point: Patients fall asleep and are blunt to respond to eyebrow taps or loud auditory stimuli; 6point: Patients fall asleep and do not respond to the above stimuli. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Time records | Anesthesia time, induction time, surgical time, awakening time and recovery time | 1 day |
| Use of drugs | The total amount of sedative and analgesic drugs used. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aihua Du, Dr | Tongji Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital | Wuhan | Hubei | 430000 | China |
You can request it from the main researcher.
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| ID | Term |
|---|---|
| C522201 | remimazolam |
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| 1 day |
| Respiratory suppression incidence | Respiratory frequency<8 times/min or SP02<90% | 1 day |
| Incidence of Treatment-Emergent Adverse Events | Intraoperative blood pressure and heart rate changes: record the patient's intraoperative blood pressure, heart rate, and the use of related vasoactive drugs; Postoperative adverse reactions: such as hypertension, hypotension, tachycardia, gastrointestinal symptoms, postoperative restlessness, etc. | 2 days |
| Incidence of PACU Adverse Reactions | Nausea and vomiting, pain (VAS score), hypotension, bradycardia, dizziness; | 1 day |