Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis

Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis

This clinical trial aimed to involve patients aged 40-85 years who had been experiencing knee pain for at least 6 months and had received a clinical diagnosis of knee osteoarthritis through radiologic imaging. The patients were randomly assigned to two groups. One group received a 3-week intra-articular injection of 15 mg/ml ozone, while the second group received a 1 ml intra-articular injection of betamethasone. All patients were evaluated before treatment, as well as 4 and 12 weeks after the first dose of treatment. The study evaluated treatment efficacy using the Visual Pain Score (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).

Inclusion Criteria:

• 40-85 years old,
• have experienced knee pain and/or limited joint range of motion for at least 6 months,
• have a diagnosis of KOA supported by radiographic imaging.

Exclusion Criteria:

• patients had undergone knee joint surgery,
• had a history of previous intra-articular injections,
• had any rheumatological disease or malignancy,
• being pregnant,
• had pain radiating to the knee and leg.