In this study, a birth cohort was established to demonstrate the causal relationship between allergies and neurodevelopment disorders in infants and young children, and to find out the influencing factors of neurodevelopment disorders in early life.

In this study, a birth cohort was established, and infants were divided into two groups according to inclusion and exclusion criteria ( see study design ). One group was allergic group, and the other group was control group. The two groups will be followed up for up to 6 years, and specimens ( blood, urine, feces ) and test data ( height, weight, GESELL, etc. ) will be retained during the follow-up period. The outcome indicators were ASD, ADHD or LD, and DSM-5 was used as the diagnostic criteria.

Inclusion Criteria:

• ①Allergic questionnaire results were positive.

  • The living area is Jinan City and its surrounding areas in Shandong Province, which is convenient for follow-up.

Exclusion Criteria:

• There is a clear diagnosis of brain developmental disorders

  • Psychological diseases

    • History of craniocerebral trauma or brain organic disease ④Major physical diseases ⑤Visual and auditory disorders ⑥ Epilepsy ⑦Intellectual disabilities

The obstetrics department of Qilu Hospital of Shandong University recruit pregnant women. After the delivery of pregnant women, the newborns will included in the cohort.