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| Name | Class |
|---|---|
| Ceren Kahraman | UNKNOWN |
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This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
Purpose: In this study, the contribution of this non-invasive follow-up method to the management of DKA and the reduction of the frequency of invasive procedures was investigated in patients diagnosed with diabetic ketoacidosis (DKA) in the pediatric emergency department and followed up with capnography
Method: This study is a prospective clinical study. Between October 2020- November 2022, EtCO2 and IPI follow-up of 0-18 year-old pediatric patients diagnosed with DKA in the Pediatric Emergency Service of Akdeniz University Medical Faculty Hospital was performed by capnography. DKA diagnosis, grading, clinical follow-up and treatment termination criteria of the patients were determined according to the ISPAD 2018 Diagnosis and Treatment Guidelines. In the study; During the clinical follow-up, changes in GCS, blood glucose, vital, blood gas and capnograph parameters were examined. Demographic data were analyzed in all patients and in groups of patients who underwent DKA grading. GCS, blood gas and capnograph parameters were compared in the patient groups with DKA grading. Diagnostic test performances of blood gas and capnograph parameters were compared to detect low GCS
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Capnography | Diagnostic Test | This is non-invasive follow-up method to the management of DKA and the reduction of the frequency of invasive procedures was investigated in patients diagnosed with diabetic ketoacidosis (DKA) in the pediatric emergency department and followed up with capnography. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between PCO2 and EtCO2 | The positive linear correlation between PCO2 and EtCO2 indicates that acidosis can be monitored with EtCO2. | 2 days |
| Correlation between Integrated Pulmonary Index and degree of acidosis | Detection of a positive linear correlation between those with Integrated Pulmonary Index <8 and the degree of acidosis | 2 days |
| Prediction of cerebral edema with Integrated Pulmonary Index | Detection of significant decrease in Glasgow Coma Scale (GCS<13) in patients with Integrated Pulmonary Index <4 | 2 days |
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Inclusion Criteria:
Exclusion Criteria:
• Who did not give written consent were not included in the study.
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During the study, 55 of 66 patients diagnosed with DKA in the pediatric emergency department of our hospital were included in the study. One of our patients was during the researcher's leave; 7 of them were excluded from the study because they were in periods when capnograph cannula was not available in our hospital and 3 of them were excluded due to patient non-compliance.
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| Name | Affiliation | Role |
|---|---|---|
| OZLEM TOLU KENDIR, Assoc. Prof. | Akdeniz University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akdeniz University | Antalya | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41033061 | Derived | Kendir OT, Kahraman C, Tekerek NU, Gurlu R, Parlak M, Erkek N. The contribution of end-tidal carbon dioxide monitoring to the management of pediatric patients with diabetic ketoacidosis. Am J Emerg Med. 2026 Jan;99:151-154. doi: 10.1016/j.ajem.2025.09.050. Epub 2025 Sep 26. |
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| ID | Term |
|---|---|
| D000138 | Acidosis |
| D016883 | Diabetic Ketoacidosis |
| D001929 | Brain Edema |
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D007662 | Ketosis |
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| ID | Term |
|---|---|
| D019296 | Capnography |
| ID | Term |
|---|---|
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D048909 |
| Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D044882 | Glucose Metabolism Disorders |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |