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The purpose of this study is to form an interdisciplinary team to dynamically evaluate patient cognitive outcomes and develop an individualized cognitive training program for Chinese brain tumor patients
Adult patients diagnosed with glioma who meet the inclusion criteria will be enrolled in this study. Patients admitted to Neurosurgery Ward 1 will be assigned to the intervention group, while those admitted to Neurosurgery Ward 2，ward 3 and Ward 4 will serve as the control group. The intervention group will receive cognitive rehabilitation training based on the Remind strategy in addition to standard rehabilitation care, whereas the control group will receive only standard rehabilitation care. Assessment of patients' cognitive function, quality of life, psychological status, and the effectiveness of cognitive training intervention will be conducted on the first day of admission, before intervention, at the end of the 4-week and 12-week intervention .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | Routine rehabilitation nursing | |
| Intervention group | Experimental | On the basis of routine rehabilitation nursing, individual cognitive rehabilitation training based on Remind strategy was given |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Individual cognitive rehabilitation training based on Remind strategy was given | Other | This training educates and learns patients from the aspects of assessment of cognitive function and strategic compensation for the impact of cognitive impairment on patients, and then conducts attention, memory and executive function training and attention retraining based on patients' cognitive function to improve patients' cognitive function |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment(MoCA) | The Montreal Cognitive Assessment (MoCA) is commonly used to assess cognitive function, typically taking about 15 minutes to complete. It has a total score of 30 points, with a score of ≥26 considered normal. Lower scores indicate more severe cognitive impairment. MoCA is advantageous due to its ease of administration, short duration, and high reliability and validity. | The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| The European Organization for Research and Treatment of Cancer core Quality of Life Questionnaire (EORTC QLQ-C30) | The European Organization for Research and Treatment of Cancer core Quality of Life Questionnaire (EORTC QLQ-C30) includes five functional scales (physical, role, cognitive, emotional, and social), three symptom scales (fatigue, pain, and nausea and vomiting), a global health and QoL scale, as well as individual items to assess other symptoms commonly experienced by cancer patients (such as dyspnea, appetite loss, sleep disturbance, constipation, and diarrhea), and the perceived economic impact of the disease and treatment. All items are scored using a 4-point Likert scale (1: 'not at all'; to 4: 'very much'), except for two items in the global health/QoL scale which use a modified 7-point linear analog scale. Higher scores indicate poorer quality of life. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| peifen ma, Master | Lanzhou University Second Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yuanyuanma | Lanzhou | Gansu | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42043588 | Derived | Ma Y, Zhou R, Ma Y, Mou C, He B, Sun D, Wu X, Dai Y, Ma P. Application of multidimensional cognitive training in the early postoperative period for glioma patients with cognitive impairment. J Neurooncol. 2026 Apr 27;177(3):128. doi: 10.1007/s11060-026-05575-7. |
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The research data is being preserved by the research team and will be presented in the published paper after the study is completed.
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| ID | Term |
|---|---|
| D005910 | Glioma |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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Non-randomized intervention study
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Blind the evaluator
|
| The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| The EORTC QLQ-Brain Neoplasms 20(EORTC QLQ-BN20) | The EORTC QLQ-Brain Neoplasms 20(EORTC QLQ-BN20) is a tool specifically designed to assess the quality of life of patients with brain tumors. The instrument consists of four multi-item scales covering: future uncertainty; visual disorders; motor dysfunction; communication deficit. Additionally, seven individual items assess headache, seizures, drowsiness, hair loss, itching, weakness of legs, and bladder control. All items and scores are evaluated on a scale of 0-100, with higher scores reflecting more severe symptoms. | The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| Self-Rating Anxiety Scale(SAS) | The Self-Rating Anxiety Scale (SAS) is used to assess the subjective feelings of anxiety patients. The scale consists of 20 items aimed at quantifying the severity of anxiety-related symptoms experienced by patients. It is divided into four levels on a Likert four-point scale: None or rarely, Sometimes, Often, and Always. Scores range from 20 to 80, with 20-44 considered normal, 45-59 indicating mild to moderate anxiety levels, 60-74 indicating severe anxiety levels, and extreme anxiety levels falling between 75 and 80. | The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| Self-Rating Depression Scale(SDS) | The Self-Rating Depression Scale (SDS) is used to assess an individual's subjective feelings of depression. The scale consists of 20 items rated on a Likert four-point scale: None or rarely, Sometimes, Often, and Always. Higher scores indicate higher levels of depression in the individual. | The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| Modified Barthel Index(MBI) | The Modified Barthel Index (MBI) is widely used in clinical practice to assess activities of daily living (ADL). It reflects patients' ability to perform self-care activities such as dressing, feeding, personal hygiene, as well as mobility activities such as sitting, standing, and walking. This scale is straightforward, easy to administer, and has good reliability and validity. | The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention. |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |