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To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lobectomy | Active Comparator | thyroid lobectomy, is recommended as first-line treatment for papillary thyroid micraocarcinima |
|
| image-guided thermal ablation | Experimental | radiofrequency ablation or microwave ablation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| thyroid lobectomy | Procedure | thyroid lobectomy |
| |
| image-guided thermal ablation |
| Measure | Description | Time Frame |
|---|---|---|
| disease progression | cervical lymph node metastases, recurrent tumors and persistent tumors | more than 5 years |
| disease-free survival | disease-free survival calculated from treatment initiation to disease progression or the last follow-up date | more than 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| complications | complications after surgery or ablation | 1 week |
| procedure time | Ablation procedure time was defined from US evaluation for the design of insertion way to treatment terminated. Lobectomy procedure time was defined from incision to closure, not including the anesthesia time. |
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Inclusion Criteria:
Exclusion Criteria:
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There is not a plan to make IPD available because of the patients privacy.
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| ID | Term |
|---|---|
| D000077273 | Thyroid Cancer, Papillary |
| ID | Term |
|---|---|
| D000231 | Adenocarcinoma, Papillary |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
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| Procedure |
radiofrequency ablation or microwave ablation or laser ablation |
|
| 1 hour after treatment |
| cost | The ablation cost included preoperative examinations, treatment, local anesthesia and ablation needle costs. The lobectomy cost included preoperative examinations, treatment, general anesthesia, hospital bed, nursing and postoperative medication | 1 week |
| estimated blood loss | estimated blood loss after surgery or ablation | 1 hour |
| hospitalization | hospitalization for surgery or ablation | 1 week |
| D009370 |
| Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D013964 | Thyroid Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D006258 | Head and Neck Neoplasms |
| D004700 | Endocrine System Diseases |
| D013959 | Thyroid Diseases |