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The goal of this observational study is to assess the pain sensitivity in tension-type headache patients. The main question it aims to answer is:
- Are signs of central sensitization present in tension-type headache?
Participants will be asked to fill out baseline questionnaires and they will be assessed during 1 test moment (static and dynamic quantitative sensory testing).
Researchers will compare tension-type headache patients with healthy controls to see if signs of central sensitization are only present in the tension-type headache group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Episodic tension-type headache | Patients with 1 - 14 days of TTH/month. |
| |
| Chronic tension-type headache | Patients with more than 14 days TTH/month |
| |
| Healthy controls | Participants without tension-type headache |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quantitative Sensory Testing | Other | Assessment of the heat and cold pain thresholds, temporal summation, conditioned pain modulation, pressure pain thresholds, electrical pain thresholds, and withdrawal reflex. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain sensitivity for heat stimuli | Hypersensitivity for heat pain. The heat stimulus will be delivered with the TSA-2, using a thermode. | Baseline |
| Pain sensitivity for cold stimuli | Hypersensitivity for cold pain. the cold stimulus will be delivered with the TSA-2, using a thermode. | Baseline |
| Pain sensitivity for electrical stimuli | Hypersensitivity for electrical pain. The electrical stimulus will be given with the Digitimer, using an electrode. | Baseline |
| Pain sensitivity for pressure | Hypersensitivity for pressure pain. Pressure will be delivered using a digital algometer. | Baseline |
| Function of the pain facilitating pathways | Temporal summation will be measured. This gives an idea of the (dys)function of the endogenous pain facilitation system. | Baseline |
| Function of the pain inhibiting pathways | Conditioned pain modulation will be measured. This gives an idea of the (dys)function of the endogenous pain inhibiting system. A noxious conditioning heat stimulus will be given at the tibial anterior muscle. A test heat or pressure stimulus will be given at the temporalis muscle. The pain-inhibits-pain paradigm will be tested. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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This study will involve participation from various populations, specifically patients with episodic tension headache, patients with chronic tension headache, and healthy pain-free controls.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jessica Van Oosterwijck, Prof | Contact | +32 9 332 69 19 | jessica.vanoosterwijck@ugent.be |
| Name | Affiliation | Role |
|---|---|---|
| Jessica Van Oosterwijck, Prof | Revalidatiewetenschappen en kinesitherapie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University | Recruiting | Ghent | East-Flanders | 9000 | Belgium |
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| ID | Term |
|---|---|
| D018781 | Tension-Type Headache |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |