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| Name | Class |
|---|---|
| The Second Affiliated Hospital of Harbin Medical University | OTHER |
| Cancer Institute and Hospital, Chinese Academy of Medical Sciences | OTHER |
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Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| negative lymph node | |||
| postive lymph node |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics | BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them | 2024.04-2026.04 |
| To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics | Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways | 2024.04-2026.04 |
| The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics | Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment | 2024.04-2026.04 |
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Stage I-III colorectal cancer patients undergoing radical surgery with complete clinical imaging, pathology, and genetic data.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xu Guan | Contact | 13141307719 | drguanxu@163.com |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |