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In Western countries, one of the major nutritional challenges requires reducing the proportion of animal proteins and increasing the proportion of vegetable proteins in the daily plate. Added to this nutritional challenge is an environmental challenge, with plant proteins being much less expensive to produce. However, plant proteins are mainly provided by cereals and legumes, a large diversity of which is necessary to cover the recommended daily intake of amino acids. However, given the collapse of cultivated biodiversity (loss of 75% in 100 years, FAO), the diversity of the supply is very reduced.
Furthermore, for several years, public health studies have indicated a chronic deficit in micronutrients (minerals/trace elements, vitamins, antioxidants) as well as fiber in the diet of the French population. This comes in particular from the impoverishment of the nutritional quality of the fruits/vegetables/cereals/legumes consumed. In general, diet plays a major role in the primary prevention of chronic diseases (cardiovascular, diabetes, cancer) including periodontal disease. Thus, a diet low in sugars, saturated fats and rich in fiber would reduce the appearance of periodontal disease by strengthening salivary capacity. However, certain pathogenic periodontal bacteria (such as Porphyromonas gingivalis) can migrate (blood, digestive or respiratory routes) to reach other organs and represent a risk factor for other chronic diseases. Thus, the prevention of periodontal diseases through diet control would also contribute to the prevention of other chronic diseases.
The benefit of plant-based diets to reduce the risk of cancer is now established. In addition, certain cereals such as spelled have superior nutritional qualities to common wheat, notably their protein content and they also contain higher quantities of certain bioactive compounds with anti-cancer properties (such as phytosterols).
Furthermore, the potential impact of the oral microbiota on chronic diseases is now being studied: in healthy adults, a dysbiotic periodontal microbiota may be likely to lead to systemic para-inflammation. It has also been shown that a dietary change (Mediterranean diet) could lead to a reduction in pathogenic bacteria in the oral microbiota (including P. gingivalis). However, the link between the introduction of cereals into the diet and the evolution of cancer risk factor bacteria in the oral microbiota has never been demonstrated.
This pilot clinical study plans to focus on the oral microbiota, with the aim of objectivizing a possible link between a modification of the diet by the introduction of cereals (einkorn type) and the evolution of certain bacteria of this microbiota. , notably P. gingivalis (but also T. forsythia, S. anginosus, A. actinomycetemcomitans, T. denticola and F. nucleatum), considered as cancer risk factors and thus observe an improvement in health status oral and general.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Einkorn Diet | Experimental | Healthy adult volunteers (not suffering from chronic pathologies) and non-smokers, having an omnivorous diet, and agreeing to change their eating habits for 3 months (reducing meat consumption by half and replacing it with einkorn). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Einkorn Diet | Other | Analysis of the oral microbiota before (T0) and after (T2) introduction of einkorn into the diet by interdental sampling, on 4 sites, pooled then analyzed by bacterial PCR. |
| Measure | Description | Time Frame |
|---|---|---|
| Total periodontal bacteria count | Comparison of the number of total bacteria and pathogens of the interdental microbiota before (T0) and after (T2) introduction of einkorn into the diet, by interdental sampling, on 4 sites, pooled then analyzed by bacterial PCR. | Baseline (T0), 3 months after baseline (T2) |
| Measure | Description | Time Frame |
|---|---|---|
| Intermediate periodontal bacteria count | Comparison of the number of total bacteria and pathogens of the interdental microbiota before (T0) and in interim analysis (T1) for evaluation of the minimum period of effectiveness, by interdental sampling, on 4 sites, pooled then analyzed by bacterial PCR. | Baseline (T0), 1 month later (T1) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maison des professionnels | Lyon | 69000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39458490 | Result | Murat-Ringot A, Lan R, Fraticelli L, Fayet Y, Bourgeois D, Nugem R, Piton M, Goetz E, Preau M, Dutertre F, Bernoud-Hubac N, Basbous L, Lastmann A, Charreyre MT, Carrouel F. An Innovative One Health Approach: BIOQUALIM, a Transdisciplinary Research Action Protocol-From Cultivated Biodiversity to Human Health Prevention. Nutrients. 2024 Oct 15;16(20):3495. doi: 10.3390/nu16203495. |
| Label | URL |
|---|---|
| Related Info | View source |
| ID | Type | URL | Comment |
|---|---|---|---|
| results | View IPD |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D006304 | Health Status |
| ID | Term |
|---|---|
| D003710 | Demography |
| D011154 | Population Characteristics |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
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|
| Intermediate oral microbiota | Other | Comparison of the number of total bacteria and pathogens of the interdental microbiota before (T0) and in interim analysis (T1) for evaluation of the minimum period of effectiveness, by interdental sampling, on 4 sites, pooled then analyzed by bacterial PCR. |
|
| Periodontal health status | Other | Analysis of the periodontal and oral clinical parameters (plaque index, gingival index, interdental inflammation, pocket depth and loss of clinical attachment, salivary pH) before (T0) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth |
|
| General health status | Other | Analysis of general health indicators (body mass index, measurement of abdominal circumference, blood pressure, MOS SF-36 quality of life questionnaire and eating habits) before (T0) and after (T2) introduction of einkorn in the diet |
|
| Periodontal health analysis:plaque index |
Comparison of periodontal and oral clinical parameters (plaque index) before (T0), intermediate (T1) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth |
| Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| Periodontal health analysis: gingival index | Comparison of periodontal and oral clinical parameters (gingival index) before (T0), intermediate (T1) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| Periodontal health analysis : pocket depth and loss of clinical attachment | Comparison of periodontal and oral clinical parameters (pocket depth and loss of clinical attachment) before (T0), intermediate (T1) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| Periodontal health analysis : interdental inflammation | Comparison of periodontal and oral clinical parameters (interdental inflammation) before (T0), intermediate (T1) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| Periodontal health analysis : salivary pH | Comparison of periodontal and oral clinical parameters (salivary pH) before (T0), intermediate (T1) and after (T2) introduction of einkorn into the diet, by sampling and periodontal analysis of all of the participants' teeth | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| General health analysis : body mass index | Comparison of general health indicators (body mass index) before (T0), intermediate (T1) and after (T2) introduction of einkorn in the diet, by a consultation and a general medical examination | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| General health analysis : measurement of abdominal circumference | Comparison of general health indicators (measurement of abdominal circumference) before (T0), intermediate (T1) and after (T2) introduction of einkorn in the diet, by a consultation and a general medical examination | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| General health analysis : blood pressure | Comparison of general health indicators (blood pressure) before (T0), intermediate (T1) and after (T2) introduction of einkorn in the diet, by a consultation and a general medical examination | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| General health analysis : MOS SF-36 quality of life questionnaire | Comparison of general health indicators (MOS SF-36 quality of life questionnaire) before (T0), intermediate (T1) and after (T2) introduction of einkorn in the diet, by a consultation and a general medical examination | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| General health analysis : eating habits | Comparison of general health indicators (eating habits) before (T0), intermediate (T1) and after (T2) introduction of einkorn in the diet, by a consultation and a general medical examination | Baseline (T0), 1 month later (T1), 3 months after baseline (T2) |
| D004778 |
| Environment and Public Health |