Prospective observational multicenter study, aimed at evaluating the effectiveness on local control and cancer-specific survival of radiochemotherapy followed by interventional radiotherapy in patients affected by vaginal cancer

Prospective observational multicenter study, aimed at evaluating the effectiveness on local control and cancer-specific survival of radiochemotherapy (45Gy on pelvis and tumor plus chemotherapy with cisplatinum) followed by interventional radiotherapy (28Gy on residual tumor) in patients affected by vaginal cancer

Inclusion Criteria:

• Age more than18 years old
• Performance status 0,1
• Hystological diagnosis of squamous vaginal cancer
• HPV, p16, p53 status
• Stage I, II, III and IV (AJCC 2018th version)
• Stadiation with magnetic resonance and positron emission tomography
• Informed consensus

Exclusion Criteria:

• Age inferior 18 years old
• Performance status more than 2
• Previous cancer in the last ten years
• Previous radiation treatment in the region of interest
• Presence of pathologies that contraindicate radiotherapy treatment (genetic syndromes of hyper-radiosensitivity, ulcerative colitis, diverticulitis in the acute phase, severe diverticulosis, chronic pelvic inflammation)
• Presence of internal pathologies that contraindicate chemotherapy or radio-chemotherapy treatment (severe liver disease, heart disease, renal failure, etc.)
• Presence of distant metastases in sites other than the pelvic lymph nodes
• Any significant medical condition that in the opinion of the investigator may interfere with the patient's optimal participation in the study

Women with vaginal cancer that after first consultation will undergo to radiochemotherapy and interventional radiotherapy