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This is a randomized trial investigating the effect of oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - on intraoperative hypotension. Specifically, the investigators will test the primary hypothesis that oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - reduces the time-weighted average mean arterial pressure below 65 mmHg in patients having non-cardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oscillometric blood pressure monitoring at 2.5-minute intervals | Experimental | In patients assigned to oscillometric blood pressure monitoring at 2.5-minute intervals, oscillometric upper-arm cuff blood pressure will be measured and displayed on the patient monitor every 2.5 minutes during surgery. Blood pressure will additionally measured with BLINDED continuous non-invasive finger-cuff blood pressure monitoring. |
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| Oscillometric blood pressure monitoring at 5-minute intervals | Active Comparator | In patients assigned to oscillometric blood pressure monitoring at 5-minute intervals, oscillometric upper-arm cuff blood pressure will be measured and displayed on the patient monitor every 5 minutes during surgery. Blood pressure will additionally measured with BLINDED continuous non-invasive finger-cuff blood pressure monitoring. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oscillometric blood pressure monitoring at 2.5-minute intervals | Other | Oscillometric blood pressure will be measured at 2.5-minute intervals during surgery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Time-weighted average mean arterial pressure <65 mmHg | The primary endpoint will be the time-weighted average mean arterial pressure <65 mmHg (continuous outcome) - defined as the area under a MAP of 65 mmHg divided by the time of continuous finger-cuff blood pressure monitoring [mmHg]. | Beginning of surgery until the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Episodes of a mean arterial pressure <50 mmHg | Absolute number of patients with at least one 1-minute episode of a mean arterial pressure <50 mmHg. | Beginning of surgery until the end of surgery |
| Norepinephrine dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Karim Kouz, MD | Universitätsklinikum Hamburg-Eppendorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf | Hamburg | 20246 | Germany |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Oscillometric blood pressure monitoring at 5-minute intervals | Other | Oscillometric blood pressure will be measured at 5-minute intervals during surgery. |
|
Time-weighted cumulative amount of norepinephrine indexed to body weight [µg/kg/min].
| Beginning of surgery until the end of surgery |