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The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, electroacupuncture combined with olfactory therapy group, and sham group with 35 people in each group. After the end of the treatment, the clinical efficacy was evaluated.
The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, and electroacupuncture combined with olfactory therapy group, and sham group with 35 people in each group. All patients were treated with conventional drugs and general supportive treatment, and on the basis of this, the electroacupuncture group was given electroacupuncture treatment at bilateral Fengchi and Gongxue, the smell suction therapy group was given the intervention of volatile oil nasal suction of Acorus calamus, and the electroacupuncture group combined with smell and suction therapy group was given electroacupuncture treatment at the same time as the electroacupuncture treatment of bilateral Fengchi and Gongxue. In the sham stimulation group, non-transdermal comfortable acupuncture will be used to make the patients experience a feeling similar to acupuncture. After the 1 month innervation,the main efficacy indicators: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Barthel Index (MBI) score, and the secondary efficacy indicators: Transcranial Doppler (TCD), near-infrared functional brain imaging , magnetic resonance examination, the heart rate,blood pressure and the State Trait Anxiety Inventory (STAI)are collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | Donepezil hydrochloride was administered at 5 mg once a day (nightly) for 30 days without adverse reactions and then increased to 10 mg once a day (nightly) for 4 weeks. | |
| Electronuchal acupuncture group treatment | Experimental | Use the neck needle to take the Fengchi and Gongxue on both sides (1.5cm directly below Fengchi point). |
|
| Smell therapy group treatment | Experimental | The volatile oil of Acorus calamus is packed in the sniffer. Smell at the sniffing end, breathe evenly, 5-10 minutes each time, 3-5 times a day, for a total of 4 weeks of treatment. |
|
| The combined treatment | Experimental | The electro-neuchal acupuncture combined with sniffing and suction therapy group is treated with sniffing and suction therapy on the basis of electro-neuchal acupuncture treatment. |
|
| normal | Other | The volatile oil of Acorus calamus is packed in the sniffer. Smell at the sniffing end, breathe evenly, 5-10 minutes each time, 3-5 times a day, for a total of 4 weeks of treatment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| control | Dietary Supplement | Donepezil hydrochloride was administered at 5 mg once a day (nightly) for 30 days without adverse reactions and then increased to 10 mg once a day (nightly) for 4 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| MoCA | Montreal Cognitive Assessment Scale | 0,4 weeks after the intervention, 8 weeks after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| MMSE | Mini-Mental State Examination | 0,4 weeks after the intervention,8 weeks after the intervention |
| MBI | Barthel index score | 0,4 weeks after the intervention,8 weeks after the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xinyun Dr LI, Doctor | Contact | 8618069783240 | lxyjasmine2010@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xinyun Li, doctor | hangzhou medical colleage | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Affiliated Zhejiang Provincial People's Hospital to Hangzhou Medical College. | Recruiting | Hangzhou | Zhejiang | 311000 | China |
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| Sham group | Sham Comparator | In the sham stimulation group, non-transdermal comfortable acupuncture will be used to make the patients experience a feeling similar to acupuncture. |
|
| Electronuchal acupuncture group treatment | Other | Electronuchal acupuncture |
|
| Smell therapy group treatment | Other | nasal suction intervention with volatile oil of Acorus calamus |
|
| Electronuchal acupuncture combined with smell and inhalation therapy group treatment | Other | On the basis of electric nuchal acupuncture treatment, sniffing and inhalation therapy is given. |
|
| Sham stimulation | Other | In the sham stimulation group, non-transdermal comfortable acupuncture will be used to make the patients experience a feeling similar to acupuncture. |
|
| TCD | Transcranial Doppler examination | 0,4 weeks after the intervention |
| Near-infrared functional imaging of the brain | Near-infrared functional imaging of the brain | 0,4 weeks after the intervention |
| Magnetic resonance scanning | Magnetic resonance scanning | 0,4 weeks after the intervention |
| the State Trait Anxiety Inventory (STAI) | the State Trait Anxiety Inventory (STAI) | 0,4 weeks after the intervention |
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D012903 | Smell |
| ID | Term |
|---|---|
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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