Point of Care Evaluation of Fibrinolysis in Sepsis

Point of Care Evaluation of Fibrinolysis in Sepsis

Impaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes. The TPA lysis time reference range is established in a cohort of healthy volunteers.

Inclusion Criteria:

• age > 18 years
• sepsis or septic shock
• vasopressors required to maintain a MAP ≥ 65 mmHg despite adequate fluid resuscitation

Exclusion Criteria:

• coagulation disorders
• ECMO therapy
• use of oral anticoagulant drugs