Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to develop robust protocols for the optimisation of novel hardware, software and exercise equipment in the magnetic resonance imaging (MRI) environment in various cohorts with cardiovascular disease (CVD) with the first study focusing on those with established heart failure with preserved ejection fraction (HFpEF) or those at risk of or with pre-HFpEF.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CMR scan on either a 1.5- or 3-Tesla scanner |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner | Other | Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner |
| Measure | Description | Time Frame |
|---|---|---|
| To develop CMR scanning protocols which acquire the highest quality images during incremental exercise using a stepper ergometer (Ergospect Cardio-stepper). | By end of study - 30/04/2023 |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the reproducibility of the exercise CMR protocols in a test-retest reproducibility sub-study | By end of study - 30/04/2023 | |
| To determine the optimal scan acquisition protocol for Magnetic Resonance Spectroscopy (MRS) both H+ and 31P using the phosphorous coil in each patient group. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Either a clinical diagnosis of HFpEF, be at risk of or pre-HFpEF
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glenfield Hospital | Leicester | United Kingdom |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| By end of study - 30/04/2023 |
| To determine the reproducibility of the MRS protocols in a test-retest reproducibility sub-study | By end of study - 30/04/2023 |