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In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date.
In this research project, the investigators want to find out how thinking difficulties become noticeable in the brain with spinal cord injury.
Participation procedure: Participants who take part will be asked to come to an examination once. The duration of the examination is between 2 and 2.5 hours (including around 55 minutes in the magnetic resonance imaging scanner, including preparation and follow-up).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| spinal cord injury | Individuals living with a spinal cord injury | ||
| non spinal cord injury | able-bodied individuals |
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| Measure | Description | Time Frame |
|---|---|---|
| Brain activity | Brain activity defined as changes in oxygen levels in the blood during the execution of cognitive tasks on cognitive inhibition and verbal fluency (executive functions), and at rest | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral performance | Accuracy on cognitive inhibition task (in percentage) | Baseline |
| Behavioral performance | Reaction time (in milliseconds) on cognitive inhibition task |
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Inclusion criteria (with and without spinal cord injury):
Additional inclusion criteria (spinal cord injury only):
Exclusion criteria (with and without spinal cord injury):
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Individuals with SCI and healthy controls will be recruited for the study considering age-matching.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Swiss Paraplegic Research | Nottwil | Canton of Lucerne | 6207 | Switzerland |
The investigators plan to save anonymised data into public repositories, but given the size of imaging data, they are still undecided.
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| Baseline |
| Behavioral performance | Number of errors on cognitive inhibition task | Baseline |
| Behavioral performance | Number of correct words on verbal fluency task | Baseline |
| Behavioral performance | Number of mistakes on verbal fluency task | Baseline |
| Brain morphometry | Volume of brain structures in cubic millimetres | Baseline |
| Level of life satisfaction | Satisfaction with Life Scale (validated questionnaire assessing life satisfaction) | Baseline |
| Level of anxiety | State-Trait Anxiety Inventory (validated questionnaire assessing anxiety) | Baseline |
| Level of pain | Validated questionnaire assessing pain severity | Baseline |
| Quality of sleep | Pittsburgh Sleep Quality Index (validated questionnaire assessing sleep quality) | Baseline |
| Level of attention and awareness | Mindful Attention and Awareness scale (validated questionnaire assessing level of attention and awareness) | Baseline |
| Motor symptom severity | Motor symptoms severity (from level A to E) based on the International Standards for Neurological Classification of spinal cord injury (ISNCSCI) | Baseline |
| Demographics | Demographic information such as age, sex and education level, as well as time since injury | Baseline |
| D014947 | Wounds and Injuries |