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| Name | Class |
|---|---|
| Norwegian University of Science and Technology | OTHER |
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CoLiQ is a clinical study designed to evaluate the clinical usefulness of circulating tumor DNA (ctDNA) markers found in blood, as a liquid biopsy for diagnosis, prognosis and follow-up of colorectal cancer. The main questions it aims to answer are: 1) Can a panel of ctDNA markers identify CRC patients among the other patients summoned for colonoscopy? and 2) Does the type, number and level of ctDNA markers vary with the subtype and clinical course of CRC? Participants will be asked to answer a questionnaire and give a blood sample at inclusion. In addition, patients with CRC will be asked to give an extra test tube at their routine treatment and follow-up blood sampling.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| liquid biopsy | Diagnostic Test | based on a panel of circulating tumor DNA markers |
| Measure | Description | Time Frame |
|---|---|---|
| Colorectal cancer | Number of patients with colorectal cancer at histology following colonoscopy | evaluated within 3 months after colonoscopy |
| Colorectal adenoma | Number of patients with colorectal adenoma at histology following colonoscopy | evaluated within 3 months after colonoscopy |
| Inflammatory bowel disease | Number of patients with inflammatory bowel disease at histology following colonoscopy | evaluated within 3 months after colonoscopy |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence | Recurrence of colorectal cancer among patients treated curatively. | Within 5 years following treatment with curative intent for colorectal cancer |
| Death | Death among patients with colorectal cancer |
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Inclusion Criteria:
Exclusion Criteria:
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Patients summoned for colonoscopy at their local public hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Eivor A Laugsand, MD, PhD | Contact | +47 74075180 | eivor.a.laugsand@ntnu.no | |
| Siv S Brenne, MD | Contact | +47 74075180 | siv.s.brenne@ntnu.no |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nord-Trøndelag Hospital Trust | Recruiting | Levanger | N-7600 | Norway |
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| Label | URL |
|---|---|
| Related Info | View source |
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Blood samples
| Within 5 years following diagnosis of colorectal cancer |
| Treatment response | Treatment response among colorectal cancer patients as measured by todays standards of follow-up (CEA, CT-scans, colonoscopy) | Within the 5 years following diagnosis of colorectal cancer |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
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| ID | Term |
|---|---|
| D000073890 | Liquid Biopsy |
| ID | Term |
|---|---|
| D001706 | Biopsy |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D008919 | Investigative Techniques |
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