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| Name | Class |
|---|---|
| Memorial Sloan Kettering Cancer Center | OTHER |
| University of Miami Sylvester Comprehensive Cancer Center | OTHER |
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Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions. These questionnaires will ask about participants' sense of meaning and purpose in life, spiritual well-being, depression and/or anxiety, and social support. Participants will then be assigned to receive either MCP-C or SP-C for 7 sessions. Participants will complete additional sets of questionnaires about 2 weeks, 6 months, and 12 months after their last session of MCP-C or SP-C. It will take between 35 and 50 minutes to complete each set of questionnaires.
After participants complete the MCP-C or SP-C sessions and all 4 sets of questionnaires, their participation in this study will end. If participants decide not to complete all 7 sessions, they may still choose to complete the questionnaires.
Participants may remain in the study and continue to receive all 7 sessions of MCP-C or SP-C even if their loved one passes away.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meaning-Centered Psychotherapy for Caregivers | Experimental | Meaning-Centered Psychotherapy for Caregivers/MCP-C |
|
| Supportive Psychotherapy for Caregivers | Active Comparator | Supportive Psychotherapy for Caregivers/SP-C standard of care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meaning-Centered Psychotherapy for Caregivers | Behavioral | MCP-C is a stakeholder-informed, innovative, manualized intervention designed to assist caregivers to connect to a sense of meaning and purpose in life, despite the challenges of caregiving. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with improved primary outcomes | Evaluate the efficacy of MCP-C versus SP-C in improving primary outcomes (i.e., sense of meaning in life, spiritual well-being) immediately post-treatment and explore maintenance in gains up to 1 year. | Up to 1 year |
| Life Attitude Profile-Revised (LAP-R) | Life Attitude Profile-Revised (LAP-R) - used to measure sense of meaning in life. The LAP-R is a 48-item instrument. Each item is rated on a 7-point Likert scale ranging from "strongly agree" to "strongly disagree." Full scale ranges from 30 to 210 with a higher score indicating a greater sense of meaning in life and a more positive attitude towards life. | Up to 1 year |
| FACIT Spiritual Well-Being Scale (SWBS) | The Spiritual Well-Being Scale (SWBS) - used to measure spiritual well-being. The SWBS is a 12-item instrument. Each item is scored from 1 to 5. Negatively worded items are reverse scored. The measure generates two sub-scales: Faith/Spirituality (0-16) and Meaning/Peace (0-32). Full scale ranges from 0 to 48. Higher scores indicate a greater sense of spiritual well-being. | Up to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital Anxiety and Depression Scale (HADS) | Hospital Anxiety and Depression Scale (HADS) - measures anxiety and depression. 14-items scale with responses scored from 0-3, scores for each subscale from 0 (normal) to 21 (severe symptoms). Scores for the entire scale is 0 to 42, with higher score indicating poorer health outcome. | Up to 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Allison Applebaum, PhD, FAPOS | Contact | 212-241-8561 | allison.applebaum@mssm.edu | |
| Morgan Loschiavo, MPH | Contact | 646-888-0225 | LoschiaM@mskcc.org |
| Name | Affiliation | Role |
|---|---|---|
| Allison Applebaum, PhD, FAPOS | Icahn School of Medicine at Mount Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami (Data Collection AND Data Analysis) | Recruiting | Miami | Florida | 33136 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41864988 | Derived | Applebaum AJ, Walsh LE, Zaider T, Baser RE, Loschiavo MJ, Breitbart WS, Lichtenthal WG. Meaning-Centered Psychotherapy for Cancer Caregivers: Study protocol of a randomized controlled trial. Trials. 2026 Mar 21;27(1):336. doi: 10.1186/s13063-026-09621-7. | |
| 41674824 | Derived | Applebaum AJJ, Walsh LE, Zaider T, Baser RE, Loschiavo MJ, Breitbart WS, Lichtenthal WG. Meaning-Centered Psychotherapy for Cancer Caregivers Study protocol of a randomized controlled trial. Res Sq [Preprint]. 2026 Feb 4:rs.3.rs-7963562. doi: 10.21203/rs.3.rs-7963562/v1. |
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Requests for deidentified individual participant data can be made from the date of publication until six years post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: MSIPinfo@mssm.edu
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| Supportive Psychotherapy for Caregivers | Behavioral | Standard of care supportive psychotherapy |
|
|
| Benefit Finding Scale (BFS) | Benefit Finding Scale (BFS) - measures benefit finding. The BFS is a 17-item instrument. Each item is scored from 1-5 (not at all, a little bit, somewhat, quite a bit, or very much). Full scale ranges from 17 to 85, with higher scores indicating greater benefit finding. | Up to 1 year |
| Caregiver Reaction Assessment (CRA) | Caregiver Reaction Assessment (CRA) - measures caregiver burden. The CRA is a 24-item instrument. Full scale ranges from 24 to 120, with higher scores indicating greater caregiving burden | Up to 1 year |
| Duke-UNC Functional Social Support Questionnaire (FSSQ) | Duke-UNC Functional Social Support Questionnaire (FSSQ) - measures social support. The FSSQ is an 8-item instrument. Each item is scored on a scale of 5-1 where 5=as much as I would like; 4=almost as much as I would like; 3=some, but would like more; 2=less than i would like, and 1=much less than I would like. Full scale ranges from 0 to 44 with higher scores indicating a higher degree of satisfaction related to social support. | Up to 1 year |
| Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) | Recruiting | Basking Ridge | New Jersey | 07920 | United States |
|
| Memorial Sloan Kettering Monmouth (Limited protocol activities) | Recruiting | Middletown | New Jersey | 07748 | United States |
|
| Memorial Sloan Kettering Bergen (Limited Protocol Activities) | Recruiting | Montvale | New Jersey | 07645 | United States |
|
| Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity) | Recruiting | Commack | New York | 11725 | United States |
|
| Memorial Sloan Kettering Westchester (Consent only) | Recruiting | Harrison | New York | 10604 | United States |
|
| Memorial Sloan Kettering Cancer Center | Recruiting | New York | New York | 10065 | United States |
|
| Memorial Sloan Kettering Nassau (Limited Protocol Activites) | Recruiting | Rockville Centre | New York | 11553 | United States |
|
| ID | Term |
|---|---|
| D000084802 | Caregiver Burden |
| ID | Term |
|---|---|
| D013315 | Stress, Psychological |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D017028 | Caregivers |
| ID | Term |
|---|---|
| D006282 | Health Personnel |
| D005159 | Health Care Facilities Workforce and Services |
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