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Effect of intravenous dexmedetomidine versus dexamethasone for management of repound pain after supraclavicular brachial plexus block.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine group will receive 0.5 mcg/kg | Experimental |
| |
| Dexamethasone group will receive 8mg/kg | Experimental |
| |
| Control group will receive equivalent volume of saline 0.9%. | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine injection | Drug | Dexmedetomidine group will receive 0.5 mcg/kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of rebound pain. | Rebound pain is defined as an increase from well-controlled to severe pain typically within 12_24 h of resolution of the nerve block. | 1year |
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Inclusion Criteria:
Patients between 20_60 years old
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wesam Nashat Ali, professor | Assistant professor | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marwa Mahmoud Rady | Asyut | Assiut Governorate | 1987 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28362032 | Background | Kolny M, Stasiowski MJ, Zuber M, Marciniak R, Chabierska E, Pluta A, Jalowiecki P, Byrczek T. Randomized, comparative study of the effectiveness of three different techniques of interscalene brachial plexus block using 0.5% ropivacaine for shoulder arthroscopy. Anaesthesiol Intensive Ther. 2017;49(1):47-52. doi: 10.5603/AIT.2017.0009. | |
| 27239291 |
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| ID | Term |
|---|---|
| D000081084 | Accidental Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
Not provided
Not provided
| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D003907 | Dexamethasone |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Dexamethasone | Drug | Dexamethasone group will receive 8mg/kg |
|
| Saline | Drug | receive equivalent volume of saline 0.9%. |
|
| Brattwall M, Jildenstal P, Warren Stomberg M, Jakobsson JG. Upper extremity nerve block: how can benefit, duration, and safety be improved? An update. F1000Res. 2016 May 18;5:F1000 Faculty Rev-907. doi: 10.12688/f1000research.7292.1. eCollection 2016. |
| 31491836 | Background | Falgas N, Sanchez-Valle R, Bargallo N, Balasa M, Fernandez-Villullas G, Bosch B, Olives J, Tort-Merino A, Antonell A, Munoz-Garcia C, Leon M, Grau O, Castellvi M, Coll-Padros N, Rami L, Redolfi A, Llado A. Hippocampal atrophy has limited usefulness as a diagnostic biomarker on the early onset Alzheimer's disease patients: A comparison between visual and quantitative assessment. Neuroimage Clin. 2019;23:101927. doi: 10.1016/j.nicl.2019.101927. Epub 2019 Jul 5. |
| 33551124 | Background | Hamilton DL. Rebound pain: distinct pain phenomenon or nonentity? Br J Anaesth. 2021 Apr;126(4):761-763. doi: 10.1016/j.bja.2020.12.034. Epub 2021 Feb 5. No abstract available. |
| 36778810 | Background | Bhatia P, Metta R. Rebound pain: Undesired, yet unexplored. J Anaesthesiol Clin Pharmacol. 2022 Oct-Dec;38(4):527-528. doi: 10.4103/joacp.joacp_435_22. Epub 2022 Dec 26. No abstract available. |
| 17695343 | Background | Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146. |
| 34945739 | Result | Hong B, Oh C, Jo Y, Chung W, Park E, Park H, Yoon S. The Effect of Intravenous Dexamethasone and Dexmedetomidine on Analgesia Duration of Supraclavicular Brachial Plexus Block: A Randomized, Four-Arm, Triple-Blinded, Placebo-Controlled Trial. J Pers Med. 2021 Dec 1;11(12):1267. doi: 10.3390/jpm11121267. |
| D011246 |
| Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |