Risk of CKD in Diabetic Patients With MAFLD

Assessing the Risk of Chronic Kidney Disease Associated With Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus

This cross-sectional study of 300 participants investigates the risk of chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes. By evaluating hepatic measurements and metabolic markers, the study aims to identify key risk factors for CKD in this population, contributing valuable insights to inform targeted interventions.

investigators plan to enroll 300 participants with type 2 DM to comprehensively investigate the risk of chronic kidney disease (CKD) in individuals diagnosed with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes mellitus.

In this study, the participant population will be grouped based on presence of MAFLD or not into 2 groups, then the group with MAFLD will be subdivided into subgroups based on the degree of hepatic involvement, considering both controlled attenuation parameter (CAP) values for steatosis and liver stiffness measurements for fibrosis via fibro scan device. This grouping strategy aims to categorize individuals into distinct cohorts, such as Low Hepatic Involvement and High Hepatic Involvement groups, facilitating a nuanced exploration of the association between hepatic conditions and the risk of chronic kidney disease (CKD) in the context of metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes mellitus.

Inclusion Criteria:

• Type 2 diabetic patients
• Willing and agreed to be included in the study.

Exclusion Criteria:

• Type 1 diabetic patients or non-diabetic patients.
• Patient with known glomerulonephritis.
• Patient with diagnosis of or clinical features that are suspicious for another systemic disease that commonly causes kidney disease (e.g., connective tissue disorders, HIV).
• Patient with evidence of alternative kidney disease like (Documented obstructive uropathy, etc.)
• Patient with history of kidney transplantation.
• Patient with end stage renal disease or on dialysis.
• Patients with active malignancy.
• Individuals with a history of hepatitis B surface antigen or hepatitis C antibody positivity.
• history of excessive alcohol consumption (⩾30 g/day in men and ⩾20 g/day in women)
• Decompensated liver cirrhosis.