Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with refractory epilepsy | Experimental | Patients will not receive any drugs, but will participate to experiments involving electroencephalograpy, pupillometry and light administration. |
|
| Healthy subjects | Experimental | Subjects will not receive any drugs, but will participate to experiments involving electroencephalograpy, pupillometry and light administration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration | Other | Recording of the electrical activity of the brain, of the heart. Pupil size will be analyzed. The effect of blue light administration will be assessed on those parameters. |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of blue light on VNS biomarkers | Blue light increases VNS induced electroencephalogram desynchronisation in implanted patients | 4 years |
| Effect of blue light on VNS biomarkers | Blue light increases P300 amplitude in VNS implanted patients | 4 years |
| Effect of blue light on VNS biomarkers | Blue light increases VNS (or tVNS) induced pupil dilation (in patients & healthy subjects). | 4 years |
Not provided
Not provided
Inclusion Criteria:
Patients:
VNS implanted since at least 3 months age >18-60 years; IQ >55 on Wechsler scale (normal status or mild cognitive impairment)
healthy participants aged between 18 and 35 years without any medical history (neurological / psychiatric disease)
Exclusion criteria:
Patients:
other medical implanted devices than VNS, ocular diseases
Helthy participants:
medical implanted devices, cerebral trauma, ocular disease
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Inci cakiroglu | Contact | +32470612917 | inci.cakiroglu@uclouvain.be |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques Universitaires Saint Luc | Recruiting | Woluwe-Saint-Lambert | 1200 | Belgium |
Not provided
Patients with refractory epilepsy (divided in non responders & responders), and healthy subjects
Not provided
Not provided
Not provided
| transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration | Other | Transcutaneous vagus nerve stimulation will be performed in helathy subjects, as well as the recording of the electrical activity of the brain, and of the heart. Pupil size will be analyzed. The effect of blue light administration will be assessed on those parameters. |
|
| ID | Term |
|---|---|
| D000069279 | Drug Resistant Epilepsy |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D005071 | Evoked Potentials |
| ID | Term |
|---|---|
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
Not provided
Not provided