Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Imperial College Healthcare NHS Trust | OTHER |
| West Hertfordshire Teaching Hospitals NHS Trust | UNKNOWN |
| Barking, Havering and Redbridge University Hospitals NHS Trust | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are:
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires.
Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oesophageal adenocarcinoma survivors | 100 disease free survivors who underwent multimodality treatment for oesophageal adenocarcinoma and are >1 year post oesophagectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breath test | Diagnostic Test | Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Identify microbiome dysbiosis in saliva associated with long-term functional symptoms. | Metagenomic sequencing of saliva samples. | 24 months |
| Identify microbiome dysbiosis in stool associated with long-term functional symptoms. | Metagenomic sequencing of stool samples. | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Identify underlying metabolic pathways associated with microbiome derived metabolites. | Bioinformatic multi-omic pathway analysis. | 36 months |
| Develop a breath test to detect volatile biomarkers associated with microbiome dysbiosis. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Disease free survivors who underwent curative treatment for oesophageal adenocarcinoma
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barking, Havering and Redbridge University Hospitals NHS Trust | London | United Kingdom | ||||
| Imperial College Healthcare NHS Trust |
Not provided
Not provided
Not provided
Not provided
| Saliva sample | Diagnostic Test | Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva. |
|
| Blood sample | Diagnostic Test | Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood. |
|
| Urine sample | Diagnostic Test | Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine. |
|
| Stool sample | Diagnostic Test | Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool. |
|
| Health-related Quality of life questionnaires | Diagnostic Test | Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires. |
|
Gas Chromatography-Mass Spectrometry (GC-MS) will be used to identify the levels (measured in parts per billion, ppb) of certain microbiome-derived VOCs in breath.
| 36 months |
| Propose a strategy for treatment of long-term symptoms in oesophageal adenocarcinoma survivors. | Identify therapeutic targets and interventions to manipulate dysbiotic microbiota | 36 months |
| London |
| United Kingdom |
| West Hertfordshire NHS Teaching Hospitals | London | United Kingdom |
| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001944 | Breath Tests |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
Not provided
Not provided