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Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand.
The development of keloids and hypertrophic scars is a consequence of insufficient wound healing. These lesions are distinguished by excessive ECM deposition. Excessive ECM deposition is caused by increased inflammatory and proliferative processes and decreased remodeling activities. These scarring lesions are also linked to genetic and systemic causes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vitamin D deficiency | Active Comparator | patients with vitamin D deficiency or insufficiency (<12 ng/ml and 12-19 ng/ml, respectively) received systemic and intralesional vitamin D injections |
|
| vitamin D sufficiency | Active Comparator | Patients with vitamin D sufficiency (20 and greater ng/mL) of vitamin D received only intralesional injections of vitamin D on hypertrophic scars and keloids. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cholecalciferol | Drug | Vitamin D has various critical regulatory roles, including inflammatory control, cellular proliferation and differentiation, and wound healing regulation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical scoring by Vancouver Scale Score | Four characteristics of the scar are assessed. These are: vascularity, height, pliability, and pigmentation. Each characteristic is given a score, which are added together to give an overall score between 0 and 13 | 3 months |
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Inclusion Criteria:
- Age from 12 years to 50 years. Patients with hypertrophic scars and keloids
Exclusion Criteria:
Age below 12 years and above 50 years. Patients received other treatment modalities for hypertrophic scars and keloids.
Systemic and other skin diseases. Patients were already receiving supplemental vitamin D.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| faculty of medicine-Fayoum university | Al Fayyum | 63519 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40135774 | Derived | Hassan AR, Binsaleh AY, El-Tahlawi SM, El-Amir AM, Ishak MM, Alsubaie N, El-Masry TA, Bahaa MM, Eldesoqui M, Kamal M. Impact of Vitamin D Injection on Keloids and Hypertrophic Scars. J Cosmet Dermatol. 2025 Apr;24(4):e70118. doi: 10.1111/jocd.70118. |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |