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The goal of this prospective randomized controlled study is to compare the therapeutic effect of injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy at different time points. At present, studies have confirmed that anti-VEGF drugs are effective in inhibiting fundus neovascularization in proliferative diabetic retinopathy. The main question it aims to answer is which time point is better to injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy.
Participants will be randomly divided into three groups. And time points of injecting anti-VEGF drugs before surgery for each group will be 3 days, 7 days, 14 days. And we have a new technology that can have fluorescein fundus angiography during operation, so it can reflect the condition of fundus neovascularization immediately and precisely. In that case, we can compare the Inhibitory effect of anti-VEGF drugs on fundus neovascularization at different time points.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Injecting anti-VEGF drugs 3 days before operation | Experimental | Injecting Conbercept into vitreous cavity 3 days before performing vitrectomy. |
|
| Injecting anti-VEGF drugs 7 days before operation | Experimental | Injecting Conbercept into vitreous cavity 7 days before performing vitrectomy. |
|
| Injecting anti-VEGF drugs 14 days before operation | Experimental | Injecting Conbercept into vitreous cavity 14 days before performing vitrectomy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Time | Other | Time point of injecting anti-VEGF drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of fundus neovascularization seen in FFA. | Fundus neovascularization | Observed during operation |
| The area of fundus neovascularization seen in FFA (using PD size as measurement). | Fundus neovascularization | Observed during operation |
| The intensity of neovascularization fluorescein leakage | 2- and 5-minute images were taken to assess the intensity of neovascularization fluorescein leakage through FFA.Fluorescein leakage intensity classification and leakage score (judged by postoperative video or jigsaw puzzle) : no leakage is 0; The suspected leakage was level 1. It is clear that the expansion range of leakage point is less than 1PD, which is grade 2. It is clear that leakage greater than or equal to 1PD is grade 3; Leakage integral is the sum of leakage number x leakage strength classification. | Observed during operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jie Li, doctor | Contact | +86 139 0809 4675 | lijieyk@med.uestc.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sichuan Academy of Medical Science Sichuan Provincial Hosptial | Recruiting | Chengdu | Sichuan | 610014 | China |
2030, via https://pan.baidu.com
2025 and forever
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| ID | Term |
|---|---|
| D013995 | Time |
| ID | Term |
|---|---|
| D055585 | Physical Phenomena |
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