To evaluate the safety and potential efficacy of combined immune cell therapy in patients with stage IV solid tumors who have failed standard treatment and have unresectable lesions or metastatic lesions.

The combined immune cell therapy has a strong potential to improve treatment outcomes in several cancers, but problems related to manufacturing complexity, immunocompatibility, and poteintial toxicity may also arise. This clinical study was designed to address these challenges and to establish the safety and potential efficacy of combined immune cell therapy for unresectable solid tumors. This is a phase I study to evaluate the safety and potential efficacy of combined immune cell theapy, and obtain the recommended dose and infusion plan.

Inclusion Criteria:

• Those who have been histologically or cytologically confirmed as adenocarcinoma among solid tumors

• Those with at least one measurable or evaliable lesion by RECIST v1.1

• Those who fail standard treatment for metastatic solid tumors (failure of treatment is defined as failure of not only progression of the disease or recurrence after treatment, but also unacceptable side effects or maintenance of the treatment process)

• ECOG performance status 0 or 1 person

• A person who can draw about 100 cc of whole blood for the manufacture of immune cells

  • Weight: More than 50 kg for men and more than 35 kg for women
  • Hb: 9.0 g/dL or higher (registerable if hemoglobin levels recover to 10.0 g/dL or higher during the screening period); however, transfusions within 7 days prior to screening to meet this standard are not allowed)

• Appropriate contraceptive regimen up to 2 months after clinical research drug administration

• A person who voluntarily decides to participate after receiving a sufficient explanation for this clinical study and agrees in writing

Exclusion Criteria:

• Brain Metastasis patients who have symptoms or need treatment [However, patients with stable brain metastasis who have no symptoms and do not need treatment (excluding anticonvulsants in maintenance therapy) can register]
• A person with a systemic disease that is inappropriate to administer anticancer drugs according to the researcher's judgment
• Those with the following cardio-cerebrovascular diseases as of the time of screening
• a person who is HIV-positive
• Those determined that the researcher was not suitable for participation in this clinical study as a result of the active infection (HBV, HCV) test
• a person with acute or severe infection
• Those who have autoimmune diseases or have a history of chronic or recurrent autoimmune diseases
• Those with a history of organ transplants
• a hematopoietic stem cell transplant patient