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There is limited research on the combined use of esketamine and alfentanil for anesthesia during facial laser treatment in pediatric patients, and the effective dosage of esketamine for inhibiting body movement remains unclear. We explore the effective dose of esketamine combined with alfentanil for the inhibition of body movement during facial laser treatment in pediatric patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| esketamine | Experimental | esketamine will be given intravenously |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Esketamine | Drug | esketamine will be given intravenously |
|
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| Measure | Description | Time Frame |
|---|---|---|
| half effective dose of inhibition of body movement | from injection of esketamine to start of laser treatment, in an average of 5 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| number of patients with agitation during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes | |
| number of patients with dizzy during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhi-Hong Lu | Contact | +862984775343 | deerlu23@163.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38317070 | Background | Zhang B, Li M, Han Y, Zhao X, Duan C, Wang J. Effective dose of propofol combined with intravenous esketamine for smooth flexible laryngeal mask airway insertion in two distinct age groups of preschool children. BMC Anesthesiol. 2024 Feb 5;24(1):50. doi: 10.1186/s12871-024-02421-z. | |
| 37464290 | Background | Su M, Zhu Y, Liu S, Song L, Qu J, Zhang Y, Zhang Q. Median effective dose (ED50) of esketamine combined with propofol for children to inhibit response of gastroscope insertion. BMC Anesthesiol. 2023 Jul 18;23(1):240. doi: 10.1186/s12871-023-02204-y. |
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The data could be shared with request to Prof. Zhihong Lu after publication of the results
after publication of the results
sending email to deerlu23@163.com
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| ID | Term |
|---|---|
| C000629870 | Esketamine |
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The Biased coin method is used
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Esketamine will be prepared by an investigator who is not involved in anesthesia and outcome assessment. For all participants, esketamine will be diluted to the same volume.
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| number of patients with nausea and vomiting during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes |
| number of patients with apnea during awake | from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes |
| satisfaction score of the parents to the anesthesia | The satisfaction of the parents to the anesthesia will be assessed by visual analogue scale, of which 0 is for extremely not satisfied, 10 is for extremely satisfied | from end of laser treatment to discharge from the outpatient unit, in an average of 60 minutes |
| 35255530 | Background | Zheng XS, Shen Y, Yang YY, He P, Wang YT, Tao YY, Zheng JJ, Sun Y. ED50 and ED95 of propofol combined with different doses of esketamine for children undergoing upper gastrointestinal endoscopy: A prospective dose-finding study using up-and-down sequential allocation method. J Clin Pharm Ther. 2022 Jul;47(7):1002-1009. doi: 10.1111/jcpt.13635. Epub 2022 Mar 7. |