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Environmental noise represents a health problem for at least one in five citizens of the European Union. Noise exposure leads to the development of arterial hypertension, myocardial infarction, stroke, and obesity. Given the limited information on noise exposure and noise effects on humans in the Republic of Serbia, the overall objective of NOXYCARD is to collect environmental noise levels data; to identify long-term and short-term noise effects on the cardiovascular system; and to evaluate the levels of blood stress hormones, oxidative stress, and inflammation in individuals with normal body weight and individuals with obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants with normal body weight | The effects of noise exposure on blood pressure, cardiovascular and hemodynamic parameters, stress hormones, and markers of oxidative stress and inflammation in individuals with normal body weight. |
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| Overweight / obese participants | The effects of noise exposure on blood pressure, cardiovascular and hemodynamic parameters, stress hormones, and markers of oxidative stress and inflammation in individuals with overweight/obesity. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure to loud pre-recorded road traffic noise | Other | Participants of both arms will be exposed to the same loud pre-recorded road traffic noise in a laboratory setting. |
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| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure | Systolic blood pressure in mmHg, higher values indicate high risk | 10, 40, and 50 minutes |
| Concentration of stress hormone | Cortisol level in mcg/dL, higher values indicate high risk | 10, 40, and 50 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Diastolic blood pressure | Diastolic blood pressure in mmHg, higher values indicate high risk | 10, 40, and 50 minutes |
| Concentration of inflammation parameters | Interleukin-1-Beta levels in pg/mL, higher values indicate high risk |
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Inclusion Criteria:
Exclusion Criteria:
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All persons who visit the Nutrition Counselling Unit of the Institute of Hygiene and Medical Ecology, located at the Faculty of Medicine, University of Belgrade will be eligible to participate in the study. The study population will include 75 participants with normal weight and 75 overweight/obese participants who meet the inclusion criteria for the survey. Participants will be informed of the protocol and sign an informed consent form.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Branko Jakovljevic, MD, PhD | Contact | +381113612762 | jakovljevic@dr.com |
| Name | Affiliation | Role |
|---|---|---|
| Katarina Paunovic, MD, PhD | University of Belgrade | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, University of Belgrade | Belgrade | Beograd | 11040 | Serbia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29459307 | Result | Paunovic K, Jakovljevic B, Stojanov V. The timeline of blood pressure changes and hemodynamic responses during an experimental noise exposure. Environ Res. 2018 May;163:249-262. doi: 10.1016/j.envres.2018.01.048. Epub 2018 Feb 22. | |
| 24529003 | Result | Paunovic K, Stojanov V, Jakovljevic B, Belojevic G. Thoracic bioelectrical impedance assessment of the hemodynamic reactions to recorded road-traffic noise in young adults. Environ Res. 2014 Feb;129:52-8. doi: 10.1016/j.envres.2014.01.001. Epub 2014 Jan 25. |
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No individual participant data will be shared. Data will be shared in cumulative form.
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| 10, 40, and 50 minutes |