eTMS for Veterans and First Responders With PTSD

Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)

A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.

Veterans and first responders diagnosed with PTSD will be studied to evaluate safety and efficacy of an EEG personalized TMS paradigm. All participants will undergo 2 days of extensive testing prior to eTMS application and 2 days of testing after. Testing will include MRI, OPM, EEG, behavioral tasks, questionnaires, and an EEG sleep study.

Inclusion Criteria:

• Veteran or first responder
• diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above

Exclusion Criteria:

• Claustrophobia
• Contraindications to MRI
• Pregnant
• Uncontrolled medical, psychological, or neurological conditions
• Unable to calculate EEG alpha frequency
• History of ECT or rTMS
• History of intracranial lesion or increased intracranial pressure
• History of stroke
• History of other neurologic conditions
• Family history of epilepsy
• Personal history of epilepsy
• certain medications