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This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients >18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total Thyroidectomy | Procedure | Total thyroidectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Central lymph node metastasis | Central neck compartment lymph node metastasis | Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively |
| Lateral lymph node metastasis | Lateral neck compartment lymph node metastasis | Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively |
| Distant metastasis | Liver and lung metastasis | Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Nuclear atypia as histological predictor of aggressiveness | nuclear atypia | The pathology report is held immediately after surgery |
| Amyloid as histological predictor of aggressiveness | amyloid |
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Inclusion Criteria:
Exclusion Criteria:
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All patients >18 years old who underwent surgery for medullary thyroid cancer are enrolled in this study
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| Name | Affiliation | Role |
|---|---|---|
| Theodossis Papavramidis, Prof | 1st Propedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Greece | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oregon Health & Science University, Oregon | Oregon City | Oregon | 97239 | United States | ||
| Department of Surgery, Saint John of God Hospital, Salzburg, Austria |
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| The pathology report is held immediately after surgery |
| Immunohistochemistry as histological predictor of aggressiveness | immunohistochemistry | The pathology report is held immediately after surgery |
| Desmoplasia as histological predictor of aggressiveness | desmoplasia | The pathology report is held immediately after surgery |
| CEA as Biochemical predictor of aggressiveness | Carcinoembryonic antigen (CEA) preoperatively and up to 1 year postoperatively | pre and postoperative laboratory exams up to 1 year postoperatively |
| Calcitonin as Biochemical predictor of aggressiveness | calcitonin levels preoperatively and up to 1 year postoperatively | pre and postoperative laboratory exams up to 1 year postoperatively |
| White blood cell as Biochemical predictor of aggressiveness | white blood cell count | pre and postoperative laboratory exams up to 1 year postoperatively |
| Platelet count as Biochemical predictor of aggressiveness | platelet count | pre and postoperative laboratory exams up to 1 year postoperatively |
| CEA drop as Biochemical cure marker | CEA drop levels | up to 1 year postoperatively |
| Calcitonin drop as Biochemical cure marker | calcitonin drop levels | up to 1 year postoperatively |
| Salzburg |
| Austria |
| Saint Luc, University Clouvain, Belgium | Brussels | Belgium |
| Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil | Santa Cruz do Sul | Brazil |
| University Clinic of Surgery, University Hospital "Lozenec" | Sofia | Bulgaria |
| Chinese University of Hong Kong | Hong Kong | China |
| Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia | Manizales | Colombia |
| the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery | Zagreb | Croatia |
| Head and Neck Surgery, Brest University Hospital, Brest, France | Brest | France |
| The University Hospital of Poitiers, France | Poitiers | France |
| Thyroid Surgery Clinic IKE, Athens, Greece | Athens | Greece |
| ENT Department University Hospital of Larissa | Larissa | Greece |
| Department of Surgery, General University Hospital of Patras | Pátrai | Greece |
| Aristotle University of Thessaloniki | Thessaloniki | Greece |
| Gennimatas General Hospital | Thessaloniki | Greece |
| Department of ENT-Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar | Bhubaneswar | India |
| KMCH and KMCH Comprehensive Cancer Center | Coimbatore | India |
| Department of Endocrine and Breast Surgery at Sanjay Gandhi Post Graduate Institute of Medical Sciences | Madurai | India |
| Department of Surgery, Maulana Azad Medical College & Lok Nayak Hospital | New Delhi | India |
| Endocrine and Metabolic Surgery, Bhargav Endocrine Hospital, Vijayawada, India | Vijayawada | India |
| University of Sulaimani | UNIVSUL ,Department of Surgery, Kurdistan | Erbil | Iraq |
| ASL VCO - San Biagio Hospital - Domodossola (VB) - Italy | Domodossola | Italy |
| Dipartimento di Scienze Chirurgiche (DISC), University of Genoa, Italy | Genoa | Italy |
| Asst Santi Paolo e Carlo - Ospedale Polo Universitario San Paolo, Milan, Italy | Milan | Italy |
| UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A Gemelli IRCCS | Roma | Italy |
| Department of Medical and Surgical Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste, Italy | Trieste | Italy |
| Department of Surgery and Oncology, Endocrine Surgery Unit, Verona University Hospital | Verona | Italy |
| Hashemite University of Zarqa | Zarqa | Jordan |
| Hepatobiliairy and endocrine surgery, Ibn Sina Hospital, Medical School of Medecine Rabat, Mohamed Vth University of Rabat Morocco | Marrakesh | Morocco |
| Division of General, Endocrine and Transplant Surgery, Medical University of Gdańsk | Gdansk | Poland |
| Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Medical School, University of Belgrade | Belgrade | Serbia |
| Comenius University in Bratislava, Department of Paediatric Surgery, National Institute of Children's Diseases | Bratislava | Slovakia |
| Department of oncological surgery, St. Elisabeth cancer Institute | Bratislava | Slovakia |
| Hospital Clinic (Barcelona, Spain) | Barcelona | Spain |
| Universitaria de Cordoba | Córdoba | Spain |
| Hospital Regional de Málaga | Málaga | Spain |
| Department of General and Digestive Surgery, Division of Endocrine Surgery, Complexo Hospitalario Universitario de Vigo, Vigo, Spain | Vigo | Spain |
| Bern University Hospital | Bern | Switzerland |
| Geneva University Hospital | Geneva | Switzerland |
| Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok, Thailand | Bangkok | Thailand |
| Ankara University Faculty of Medicine, Department of Endocrine Surgery | Ankara | Turkey (Türkiye) |
| Acibadem MAA University | Istanbul | Turkey (Türkiye) |
| Cerrahpasa medical faculty endocrine surgery department | Istanbul | Turkey (Türkiye) |
| Department of Endocrin Pathology Unit, University of Health Sciences, Faculty of Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey | Istanbul | Turkey (Türkiye) |
| Endocrine surgeon-consultant, International medical center "CITIDOCTOR" | Kyiv | Ukraine |
| Department of Radiology, Thien Hanh Hospital, Buon Ma Thuot, Vietnam | Viet Tri | Vietnam |
| ID | Term |
|---|---|
| D018276 | Carcinoma, Medullary |
| ID | Term |
|---|---|
| D018278 | Carcinoma, Neuroendocrine |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D018299 | Neoplasms, Ductal, Lobular, and Medullary |
| D009380 | Neoplasms, Nerve Tissue |
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