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| Name | Class |
|---|---|
| Ministere de la Sante et des Services Sociaux | OTHER |
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This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.
Daily vaping device users will be recruited in the Quebec City metropolitan area. Subjects will be asked to perform pulmonary function tests (spirometry, oscillometry, plethysmography, methacholine provocation) every 6 months for a 5-year follow up. Subjects will also answer a questionnaire assessing their vaping, tobacco and cannabis smoking habits, as well as their perceived respiratory symptoms. Blood draws and sputum inductions will be performed for cell counts and to measure inflammation markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Daily electronic cigarette users | Participants must use their vaping device everyday at time of enrollment. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vaping | Other | Participants use their vaping products at their own discretion and their intake is monitored via questionnaires. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who vape daily with impaired lung volumes. | Participants will perform plethysmography assessments to measure changes in lung volumes. Data will be expressed as a percentage of predicted values. | Every 6 months for 5 years |
| Number of participants who vape daily with impaired lung diffusion capacity. | Participants will perform diffusion capacity of the lung for carbon monoxide (DLCO) measures to assess changes in lung diffusion capacity. Data will be expressed as a percentage of predicted values. | Every 6 months for 5 years |
| Number of participants who vape daily with impaired spirometry. | Participants will perform spirometry tests measures to assess changes in forced expiratory lung volumes. Data will be expressed as a percentage of predicted values. | Every 6 months for 5 years |
| Number of participants who vape daily with airway hyperresponsiveness. | Participants will perform methacholine provocation challenge measures to assess changes in airway hyperresponsiveness. Data will be expressed as the methacholine concentration inducing a fall of 20% of forced expiratory volume in the first second assessed (PC20). | Every 6 months for 5 years |
| Number of participants who vape daily with changes in blood cell count. | Participants will perform a blood draw to assess blood cell count. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count. | Every 6 months for 5 years |
| Number of participants who vape daily with changes in sputum cell count. |
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Inclusion Criteria:
Exclusion Criteria:
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We seek to recruit 250 volunteers from the community with twice-a-year visits for a 5-year follow-up. We will recruit healthy volunteers as well as volunteers who have been previously diagnosed with chronic illness.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ariane Lechasseur, PhD | Contact | 418-656-8711 | 2652 | ariane.lechasseur@criucpq.ulaval.ca |
| Mathieu C Morissette, PhD | Contact | 418-656-8711 | 5394 | mathieu.morissette@criucpq.ulaval.ca |
| Name | Affiliation | Role |
|---|---|---|
| Mathieu C Morissette, PhD | Laval University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IUCPQ-UL | Recruiting | Québec | G1V 4G5 | Canada |
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| ID | Term |
|---|---|
| D000072137 | Vaping |
| D055370 | Lung Injury |
| ID | Term |
|---|---|
| D012907 | Smoking |
| D001519 | Behavior |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D066300 | Electronic Nicotine Delivery Systems |
| ID | Term |
|---|---|
| D000074602 | Smoking Devices |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
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Buffy coat obtained from plasma
Participants will perform sputum inductions to assess cell count in the sputum. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count. |
| Every 6 months for 5 years |
| Vaping, tobacco and cannabis smoking habits of participants. | Participants will complete questionnaires assessing their vaping habits, tobacco smoking and cannabis smoking history. | Every 3 months for 5 years |
| D013898 |
| Thoracic Injuries |
| D014947 | Wounds and Injuries |