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| Name | Class |
|---|---|
| Saint-Louis Hospital, Paris, France | OTHER |
| Bichat Hospital | OTHER |
| Saint Antoine University Hospital | OTHER |
| Institut National de la Santé Et de la Recherche Médicale, France |
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Immunovirological follow-up and safety of HIV-infected patients receiving lenacapavir under compassionate access in France between 01/01/2021 and 12/31/2023
Retrospective descriptive cohort of patients who received Lenacapavir under compassionate access in France with 50 patients in 25 sites in France
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| Measure | Description | Time Frame |
|---|---|---|
| proportion of participants with plasma HIV RNA < 50 copies/ml 26 weeks after first LEN injection | Week 26 |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of side effects and laboratory abnormalities on LEN treatment | between week 26 and Week 52 | |
| evolution of HIV-1 or HIV-2 RNA over time | between week 26 and Week 52 | |
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Inclusion Criteria:
Exclusion Criteria:
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Patients already followed and identified in the centers and having received lenacapavir in compassionate access between January 01st, 2021 and December 20th, 2022
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de la Côte Basque | Bayonne | France | 64100 | France | ||
| Hôpital Béclère |
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| OTHER_GOV |
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| evolution of CD4, CD8 lymphocyte counts and CD4/CD8 ratio over time |
| between week 26 and Week 52 |
| Proportion of patients with capsid resistance mutations emergence at time of virological failure response) compared with initiation (D0) | between Week 26 and Week 52 |
| Determination by multivariate analysis of factors associated with virological success 26 weeks after the first LEN injection factors associated with virological control 26 weeks after the first LEN injection | Week 26 |
| Clamart |
| France |
| 92140 |
| France |
| Hôpital de la Rochelle | La Rochelle | France | 17000 | France |
| Hôpital Bicêtre | Le Kremlin-Bicêtre | France | 94270 | France |
| Hôpital Max Fourestier | Nanterre | France | 92000 | France |
| CHU La Source | Orléans | France | 45100 | France |
| Hôpital Félix Guyon | Saint-Denis | LA Reunion | 97400 | France |
| Hopital Zobda Quitman | Fort-de-France | Martinique | 97261 | France |
| Hopital Avicenne | Bobigny | 93000 | France |
| Hôpital Pellegrin - Service de Médecine Interne et Maladies Infectieuses | Bordeaux | 33000 | France |
| Hopital Saint-Andre | Bordeaux | 33075 | France |
| Hopital Raymond Poincare | Garches | 92380 | France |
| C.H.D de Vendee | La Roche-sur-Yon | 85925 | France |
| André Mignot Hospital | Le Chesnay | 78150 | France |
| Centre Hospitalier Bretagne Sud - Hôpital du Scorff | Lorient | 56100 | France |
| CHU de Nice | Nice | 06200 | France |
| Hôpital Hotel Dieu | Paris | 75004 | France |
| Hopital Saint Antoine | Paris | 75012 | France |
| Groupe Hospitalier Pitié-Salpêtrière - Service de Maladies Infectieuses et Tropicales | Paris | 75013 | France |
| Hopital Necker | Paris | 75015 | France |
| Bichat Hospital | Paris | 75018 | France |
| Delafontaine | Saint-Denis | 93200 | France |
| Hopital Foch | Suresnes | 92150 | France |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
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