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It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. The study participants include a control group and a group with COPD (GOLD I-III). Participants are undergoing three study days: (1) Measurement of maximal aerobic capacity and lung function test, (2) lung tissue mass and alveolar-capillary permeability is measured at rest and again 2 hours later, immediately after the participant has exercised on a bicycle ergometer and (3) supine cardiac output and pulmonary capillary blood volume will be measured at rest and immediately after exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Experimental | This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits |
|
| COPD group | Experimental | This arm consist of only COPD patients, which will undergo three study visits |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute exercise bout on visit 2 and 3 | Other | 1) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload. |
| Measure | Description | Time Frame |
|---|---|---|
| Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls | The physiological change from rest to exercise in DTPA clearance | Measured at study day 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary DTPA clearance at rest in COPD vs. controls | Pulmonary DTPA clearance measured by pulmonary DTPA clearance at rest | Measured at study day 2 |
| Pulmonary DTPA clearance after exercise in COPD vs. controls |
| Measure | Description | Time Frame |
|---|---|---|
| Lung tissue mass at rest in COPD vs. controls | Lung tissue mass measured at rest by low-dose CT-scan | Measured at study day 2 |
| Lung tissue mass after exercise in COPD vs. controls | Lung tissue mass measured at exercise by low-dose CT-scan |
Inclusion criteria - individuals with COPD
Inclusion criteria - healthy controls
Exclusion criteria - individuals with COPD
Exclusion criteria - healthy controls
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center For Physical Activity Research, Rigshospitalet | Copenhagen | Denmark |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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Pulmonary DTPA clearance measured by pulmonary DTPA clearance after exercise
| Measured at study day 2 |
| Rest-to-exercise change in lung tissue mass in COPD vs. controls | The physiological change from rest to exercise in lung tissue mass measured by low-dose CT-scan | Measured at study day 2 |
| Measured at study day 2 |
| Rest-to-exercise pulmonary DTPA clearance and lung tissue mass change according to GOLD | The physiological change from rest to exercise in lung tissue mass measured by low-dose CT-scan and the physiological change from rest to exercise in DTPA clearance according to different GOLD stages | Measured at study day 2 |
| Supine pulmonary capillary blood volume after exercise in COPD vs. controls | Pulmonary capillary blood volume (VC) after exercise obtained by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine cardiac output after exercise in COPD vs. controls | Cardiac output measured after exercise by a Finometer device | Measured at study day 3 |
| Supine pulmonary capillary blood volume at rest in COPD vs. controls | VC at rest obtained by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine cardiac output at rest in COPD vs. controls | Cardiac output measured at rest by a Finometer device | Measured at study day 3 |
| Supine pulmonary diffusing capacity to nitric oxide (DLNO) after exercise in COPD vs. controls | DLNO measured after exercise by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine haemoglobin-corrected pulmonary diffusing capacity to carbon monoxide (DLCOc) after exercise in COPD vs. controls | DLCOc measured after exercise by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine alveolar-capillary membrane diffusing capacity (DM) after exercise in COPD vs. controls | Membrane diffusion capacity (DM) after exercise obtained by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine pulmonary diffusing capacity to nitric oxide (DLNO) at rest in COPD vs. controls | DLNO measured at rest by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine haemoglobin-corrected pulmonary diffusing capacity to carbon monoxide (DLCOc) at rest in COPD vs. controls | DLCOc measured at rest by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| Supine alveolar-capillary membrane diffusing capacity (DM) at rest in COPD vs. controls | DM after exercise obtained by combined DLCO/NO technique with 5-sec breath-hold | Measured at study day 3 |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |