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The goal of this observational and prospective study is to investigate changes in physical performance, lung function, respiratory and peripheral muscle strength in patients during the postoperative period following pulmonary endarterectomy (PET).
This study aims to investigate the physical changes in patients undergoing pulmonary endarterectomy (PET). It will observe alterations in physical performance, lung function, and muscle strength during the postoperative period. This study, observational and prospective, will include individuals aged ≥18 scheduled, evaluating them preoperatively, post-intensive care unit discharge, before hospital discharge and after six months . Assessments involve tests like the Six-minute walk test, Short Physical Performance Battery, One-minute sit-to-stand test, manovacuometry, dynamometry, spirometry and Clinical Frailty Scale to identify frailty and measure muscle and lung function. The study also aims to explore predictive variables for functional loss during hospitalization.
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| Measure | Description | Time Frame |
|---|---|---|
| To investigate changes in physical performance measured by Six-Minute Walk Test. | Measures: the assessment will take place in a flat 30-meter corridor, marked every 1 meter with non-slip flooring, and the patient will be instructed to walk for six minutes as fast as possible. | Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery. |
| To investigate changes in physical performance measured by Short Physical Performance Battery (SPPB). | Measure: global score | Baseline (one day before the surgery), after the surgery (the day immediately after ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after surgery. |
| To investigate changes in physical performance by 1-minute sit-to-stand test (1-MSTST). | Measure: number of 1-MSTST repetitions. | Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery |
| To investigate changes in peripheral muscle strength. | Measure: hand grip strengh (Kgf). | Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery |
| To investigate changes in respiratory muscle strength: | Measures: manovacuometry (cmH2O) | Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery |
| Measure | Description | Time Frame |
|---|---|---|
| To explore potential preoperative and immediate postoperative risk factors as predictors of functional loss. | Measures: Occurrence of comorbidities and clinical variables associated with functional decline. | Baseline (one day before the surgery) during the immediate postoperative period. |
| To investigate changes in hemodynamic and respiratory variables during the funcional tests. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients in the preoperative period of elective pulmonary endarterectomy susrgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rafael M Ianotti, PT | Contact | +55 11 26615319 | rafael.ianotti@hc.fm.usp.br |
| Name | Affiliation | Role |
|---|---|---|
| Rafael M Ianotti, PT | Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | Recruiting | São Paulo | São Paulo | 05403-000 | Brazil |
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| To investigate changes in lung function test measure by spirometry: |
| Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery |
| To investigate frailty by Clinical Frailty Scale (CFS) | The minimal value is 1 and the maximal is 9 in which the lowest scores mean worse outcomes. | Baseline (one day before the surgery), after the surgery (the day immediately ICU discharge), before the hospital discharge (an average of 20 days) and 6 months after the surgery |
| Immediateley before and after each functional test. |