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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
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The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to
Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bvYOD | Neuropsychological assessment and driving simulator task. |
| |
| non-bvYOD | Neuropsychological assessment and driving simulator task. |
| |
| Patients with frontal brain damage | Neuropsychological assessment and driving simulator task. |
| |
| Healthy controls | Neuropsychological assessment and driving simulator task. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological assessment, driving simulator task | Other | Neuropsychological assessment consisting of test measuring general cognitive abilities and social cognition. Driving simulator task measuring risk-taking. |
| Measure | Description | Time Frame |
|---|---|---|
| Social cognitive performance | Social cognition in bvYOD, compared to non-bvYOD, patients with frontal brain injury and healthy controls | 2024-2027 |
| Measure | Description | Time Frame |
|---|---|---|
| Association between social cognition and risky decision-making | Association between several aspect of social cognition (i.e. emotion recognition, empathy, theory of mind, emotion experience) and risk-taking behaviour. | 2024-2027 |
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Inclusion Criteria:
All subjects
bvYOD subjects
Non-bvYOD subjects
Frontal brain injury subjects
- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients).
Exclusion Criteria:
All subjects
YOD subjects:
- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia.
Frontal brain injury subjects:
- Presence of serious psychiatric disorders or other neurological comorbidities.
Healthy control subjects:
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Patients with young-onset dementia, i.e. onset of dementia before the age of 65 years.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gelmers | Contact | +31 50 361 46 64 | f.gelmers@umcg.nl |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40424326 | Derived | Gelmers F, Huitema RB, Scheenen ME, van Munster BC, Spikman JM; YOD-INCLUDED Consortium. Assessing social cognition and risk-taking behaviour in patients with young-onset dementia: Study protocol for the YOD-RiSoCo observational prospective cohort study. PLoS One. 2025 May 27;20(5):e0324517. doi: 10.1371/journal.pone.0324517. eCollection 2025. |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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