The study of the microcirculation and glycocalyx could be an essential element in the monitoring of our patients undergoing major abdominal surgery. It would enable us to better target the objectives of anaesthesia and resuscitation, which until now have been based essentially on macro-circulatory parameters.

This monitoring is possible in real time and real conditions by micro-camera GlycoCheck™ (Microvascular Health Solutions Inc., Salt Lake City, Utah, USA), a non-invasive monitoring allowing the study of sublingual microcirculation and glycocalyx.

Inclusion Criteria:

For the HIPEC group :

• Adult patients
• Age < 75 years
• Receiving HIPEC for primary or secondary peritoneal carcinosis

For the CDP group :

• Adult patient
• Age < 75 years
• Receiving CDP for pancreatic neoplasia
• Patient who has read and understood the information letter and does not object to taking part in the study
• Patient affiliated to a social security scheme

Exclusion Criteria:

• Secondary distant peritoneal metastases
• Chronic heart failure
• Chronic liver failure at stage C of the Child-Pugh score
• Stage IV or V chronic renal failure
• Inflammation of the sublingual buccal mucosa or injury that may locally influence sublingual microcirculation
• Patient refusal
• Person deprived of liberty by an administrative or judicial decision or person placed under court protection or guardianship

Patient undergoing major abdominal surgery by cytoreduction combined with an intraperitoneal chemotherapy bath (HIPEC) or cephalic duodeno-pancreatectomy (CDP) with epidural analgesia planned in accordance with the department's usual practice