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This study is to develop a predictive model for cardiocerebrovascular risk factors in elderly patients with essential hypertension with Telmisartan, Amlodipine, and Chlorthalidone Fixed-Dose Combination.
This is a phase IV, open-label, prospective, long-term cohort, observational study to identify the predictive model of cardiocerebrovascular risk factors in elderly patients with more than three antihypertensive agents in patients with essential hypertension in Korea.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Telmisartan/Amlodipine/Chlorthalidone(Truset) | Drug | Telmisartan/Amlodipine/Chlorthalidone 40/5/12.5 mg or Telmisartan/Amlodipine/Chlorthalidone 80/5/12.5 mg or Telmisartan/Amlodipine/Chlorthalidone 80/5/25 mg |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of MACCE(Major Adverse Cardiovascular and Cerebrovascular Events) | Percentage of MACCE(Major Adverse Cardiovascular and Cerebrovascular Events) after treatment at 12, 24 and 36months if applicable | 12, 24 and 36months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of MACCE(Major Adverse Cardiovascular and Cerebrovascular Events) in patients with asymptomatic target organ damage | Percentage of MACCE(Major Adverse Cardiovascular and Cerebrovascular Events) in patients with asymptomatic target organ damage after treatment at 12, 24 and 36months if applicable | 12, 24 and 36months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients in General Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Changhoon Lee | Veterans Health Service Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Busan Veterans Hospital | Busan | 46996 | South Korea | |||
| Daegu Veterans Hospital |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000077333 | Telmisartan |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Mean Systolic Blood Pressure (MSBP)/ Diastolic Blood Pressure (MDBP) |
To evaluate change from baseline in Mean Systolic Blood Pressure (MSBP)/ Diastolic Blood Pressure (MDBP) measured by the Institution at 12, 24 and 36months if applicable |
| 12, 24 and 36months |
| Patients Achieving the treatment goal in Mean Systolic Blood Pressure (MSBP) | To evaluate the percentage of patients who reached the treatment goal for Mean Sitting Blood Pressure (MSBP) < 140/90 mmHg measured by the Institution at 12, 24 and 36months if applicable | 36months |
| Percentage of patients who terminated the treatment | To evaluate the percentage of patients who terminated the treatment before 36 months | 36months |
| Daegu |
| 42835 |
| South Korea |
| Gwangju Veterans Hospital | Gwangju | 62284 | South Korea |
| Konkuk University Medical Center | Seoul | 05030 | South Korea |
| Veterans Health Service Medical Center | Seoul | 05368 | South Korea |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |