SUPERvised Three-month Exercise Program in MEN With Prostate cAncer Receiving Androgen-deprivaTioN thERapy

SUPERvised Three-month Exercise Program in MEN With Prostate cAncer Receiving Androgen-deprivaTioN thERapy

The goal of this single blind placebo-controlled intervention study is to examine the impact of a supervised training program on disease-related quality of life and physical fitness in patient with advanced prostate cancer compared to usual care. The main question[s] it aims to answer are:

• What is the impact of exercise on quality of life
• What is the impact of exercise on physical fitness

Participants will have an individual training program with supervised training by physiotherapists.

Researchers will compare with usual care to see if advice about exercise has significant less effect than an supervised training program.

Inclusion Criteria:

• Signed informed consent
• Age > 18 years old
• Able to read and complete questionnaires in Dutch
• Proven histologically and /or radiologically metastatic prostate cancer (TxNxM1)

Exclusion Criteria:

• Other cancers
• Clinicians' judgement
• Age >80 years old or not able to walk 400m
• Structural exercise (moderate-intensity exercise more than 150 minutes a week) during the past 3 months
• Musculoskeletal, cardiovascular, or neurological disorders that could inhibit them from exercising
• Spinal cord compression, history of pathological fractures