Randomized clinical study analyzing the efficacy of colonoscopy assisted by the Computer Aided Detection (CADe) system compared to virtual chromoendoscopy with Narrow Band Imaging (NBI) in the detection of colon dysplasia in patients with long-standing inflammatory bowel disease (IBD).

INCLUSION CRITERIA:

• Adults (age ≥18 years).
• Patients with IBD meeting the following criteria:
• Diagnosis of IBD confirmed by clinical and histological evidence.
• Disease extent (Montreal classification): 1) For Ulcerative Colitis (UC), Extensive colitis (E3): involvement proximal to the splenic flexure; or, Left-sided colitis (E2): involvement distal to the splenic flexure. 2) For Crohn's Disease (CD): Colon-only involvement (L2); or, Ileocolonic involvement (L3).
• Disease duration > 7 years.
• Patients with concommitant Primary Sclerosing Cholangitis, regardless of the extent of colonic involvement and disease duration.
• Written consent from the patient to undergo colonoscopy (signed informed consent).

EXCLUSION CRITERIA:

• Personal history of colorectal cancer (CRC).
• Previous colectomy (partial or complete).
• Coagulopathy preventing biopsy or polypectomy/mucosal resection.
• Colonoscopy performed in the last 6 months.
• Pregnant or lactating women.
• Ulcerative colitis with involvement limited to the rectum or Proctitis (Montreal E1).
• Inadequate colonic preparation due to uncleavable fecal residue during colonoscopy: Boston Bowel Preparation Scale (BBPS) = 0 or 1 in any colon segment.
• Presence of inflammatory activity due to IBD on endoscopy:1) For UC: Endoscopic Mayo Score ≥ 2. 2) For CD: Simplified Endoscopic Activity Score (SES-CD) > 5.
• Incomplete lower digestive endoscopy (failure to reach the cecum).