Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this interventional study is to test the effect of the anti-inflammatory and neuroprotective effects of this supplementary training program that includes breathing exercises, cold exposure, and meditation in patients diagnosed with multiple sclerosis.
Researchers will compare the effect to control groups of MS patients without intervention.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention group | Experimental |
| |
| control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wim Hoff method | Combination Product | breathing exercises, cold exposure, and meditation |
|
| Measure | Description | Time Frame |
|---|---|---|
| concentration of pro-inflammatory cytokines | blood concentrations in pg/ml of • cytokines (interleukins - IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33, interferons IFN-α2 and IFN-γ, tumor necrosis factor TNF-α, monocyte chemoattractant protein MCP-1) | 12 weeks |
| concentration of markers of oxidative stress | blood concentration in mmol/l of markers of oxidative stress (OS) - advanced glycation end products (AGEs), fructosamine, advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), ferric reducing ability of plasma (FRAP), | 12 weeks |
| concentration of NfL | neurofilamen light chains | 12 weeks |
| concentration of GFAP | glial fibrillary acidic protein | 12 weeks |
| concentration of ecDNA | cell-free extracellular DNA | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Expanded Disability Status Scale | physical disability - score from 0.0 to 10.0 | 12 weeks |
| Timed 25-Foot Walk | walking speed in seconds |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Derer's University Hospital | Bratislava | 83305 | Slovakia |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 12 weeks |
| Nine-Hole Peg Test | finger dexterity in seconds | 12 weeks |
| Symbol Digit Modalities Test | cognitive status - score in 90s | 12 weeks |
| Fatigue Scale for Motor and Cognitive Functions | to assess multiple sclerosis-related fatigue | 12 weeks |
| General Anxiety Disorder-7 | level of anxiety | 12 weeks |
| Patient Health Questionnaire-9 | assesses degree of depression severity | 12 weeks |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |