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This is a health services intervention study aimed at understanding the impact of intensive multi-disciplinary care compared with standard care on patient-reported symptom outcomes and prognostic awareness in patients with brain metastases.
This is a cohort study of patient with newly diagnosed brain metastases assigned to standard of care (SOC) or intensive multi-disciplinary care (IMDC). Care for all patients with brain metastases involves complex medical decision making and requires input for multiple stakeholders, including medical oncology, neurosurgery, radiation oncology, and neuro-oncology. Palliative care should be an essential component of the care team for all patients with brain metastases by the very nature of this advanced malignancy. At the University of Vermont, our current process for diagnosis and management of patients with brain metastases relies heavily on the physician and team who make the initial diagnosis to consult others as they see appropriate. This process may look different for different patients. We rationalize that a systematic approach with intensive multidisciplinary care (IMDC) will benefit patients with brain metastases by providing consistent access to multi-disciplinary discussion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard of Care | Active Comparator |
| |
| Multidisciplinary Care | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| health services intervention | Other | Health services intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patient reported outcomes | Symptom burden based on patient reporting on Brain Mets Symptom Inventory | 6-12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility | Number of % of patients able to complete protocol-specified activities | 6-12 months |
| Patient understanding of prognosis | Concordance with physician predication of prognosis |
| Measure | Description | Time Frame |
|---|---|---|
| Exploratory survival outcome | 90 day and 1 year survival | 6-12 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alissa A Thomas, MD | Contact | 802-847-8400 | athoma21@med.uvm.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vermont Medical Center | Recruiting | Burlington | Vermont | 05401 | United States |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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cohort study
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| 6-12 months |
| survival | Survival outcomes for patients receiving best supportive care | 6-12 months |
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |