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A randomized trial assessing the effectiveness of virtual reality exposure prior to an oocyte retrieval procedure in terms of anxiety level .
Eligible women, undergoing elective egg freezing, will be offered to participate in the study, and sign a consent form.
The patients will be randomized into 2 groups:
All women will be addressed prior to the procedure, while they are waiting, and upon consent will be asked to state their VAS (visual analogue scale) anxiety score and to fill the STAI (The State-Trait Anxiety Inventory questionnaire.) Vital signs (Heart rate, Blood pressure) will be recorded upon arrival.
Patients who were allocated to the VR arm will watch a 20-minute scenery video and following the session before entering the procedure will be asked to rate their VAS score and answer the STAI questionnaire once again. vital signs will be recorded again.
After recovery all women will fill the STAI questionnaire, VAS score and vital signs before they will be discharged.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Routine management | No Intervention | Usual care of patients prior to a surgical procedure : oocyte retrieval | |
| Virtual reality management | Experimental | 20 minutes of scenery VR movies prior to the surgical procedure (oocyte retrieval) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The VR instrument - Oculus Quest 2 | Device | Patients in the interventional group will watch 20-minute scenery movies in the VR instrument before entering the oocyte retrieval procedure. |
| Measure | Description | Time Frame |
|---|---|---|
| Vital signs | Blood pressure (systolic+ diastolic levels) | Up to 8 hours from admission. (Admission, pre-procedural, discharge) |
| Vital signs | Heart rate (Beats per minute) | Up to 8 hours from admission. (Admission, pre-procedural, discharge) |
| VAS (visual-analogue scale) | VAS anxiety score (1-10), Higher levels indicate higher anxiety levels. | Up to 8 hours from admission. (Admission, pre-procedural, discharge) |
| State and Trait Anxiety (STAI) Score | The patient's anxiety levels will be assessed using the STAI questionnaire, higher numbers in the questionnaire indicate higher anxiety levels. Levels up to 30 indicate low anxiety, between 30-45 moderate anxiety, more than 46 high anxiety levels. | Up to 8 hours from admission. (Admission, pre-procedural, discharge) |
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Inclusion Criteria:
Exclusion Criteria:
Use of any medications for pain relief/ anti -anxiety /anti -depressants medication generally or prior to the intervention
If suffers from any condition that Use of VR is not recommended:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anat Hershko-Klement, M.D | Contact | +972549170084 | anat.klement@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hadassah mound scopus IVF unit | Recruiting | Jerusalem | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40632426 | Derived | Suissa-Cohen Y, Frenkel R, Nevo L, Kam HA, Bentov Y, Godin M, Broder EE, Hizkiyahu R, Lazarovits CA, Beharier O, Klement AH. Virtual reality-based intervention to improve pre-operative anxiety in patients undergoing planned oocyte cryopreservation: a randomized clinical trial. J Assist Reprod Genet. 2025 Sep;42(9):2995-3002. doi: 10.1007/s10815-025-03571-w. Epub 2025 Jul 9. |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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