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| Name | Class |
|---|---|
| National Medical Research Radiological Centre of the Ministry of Health of Russia | OTHER |
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Esophageal and esophagogastric junction cancer is still one of the main health care issue and esophagectomy with lymph node dissection is the only chance to be cure.
However, esophagectomy for esophageal cancer is a complex procedure which carries high risk of morbidity rate of 24% and a mortality rate of 2% to 5.6%, respectively There is a need to study the differences of 90-day postoperative morbidity and mortality in different clinics and centers of the Russian Federation.
Esophageal and esophago-gastric junction cancer is the seventh most common malignancy and the sixth leading cause of cancer-related mortality worldwide.
Surgery remains the primary treatment for esophageal cancer and is one of the most technically challenging interventions in oncological surgery. In addition, esophagectomy is associated with high risks of postoperative complications, with rates varying from clinic to clinic. Esophagectomy for esophageal cancer is a complex procedure which carries high risk of morbidity rate of 24% and a mortality rate of 2% to 5.6%, respectively.
The problem with the available studies of the course of the postoperative period is the significant heterogeneity of research methods, which does not allow us to obtain a true picture of the results of surgical treatment of the esophagus and esophagogastric junction cancer in the Russian Federation.
To improve the quality of further studies and recommendations on standardization of surgical treatment of esophageal and esophagogastric junction cancer and its morbidity, there is a need to study the differences of 90-day postoperative morbidity and mortality in different clinics and centers of the Russian Federation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with morbidity and mortality | Patients who suffered from any type of morbidity after surgery |
| |
| Patients without morbidity and mortality | Patients who did not suffer from any type of morbidity after surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Elective Surgery for gastric cancer | Procedure | Resection of the esophagus and the gastroesophageal junction via open, laparoscopic or robotic approach |
|
| Measure | Description | Time Frame |
|---|---|---|
| the type of complications and the incidence of it | the types of complication is classified into as follows: gastrointestinal (anastomotic leak, conduit necrosis/failure, pancreatitis, GI Bleeding, delayed conduit emptying); pulmonary (pneumonia, pleural effusion, pneumothorax, respiratory failure, ARDS, acute aspiration, tracheobronchial Injury); cardiac; thromboembolic; urologic; infection (wound infection; intrathoracic/intra-abdominal abscess; generalized sepsis; other infections); neurologic (recurrent nerve injury, acute delirium) and other (thoracic wound dehiscence, diaphragmatic hernia, chyle leak, reoperation other than for anastomotic leak or conduit necrosis, multiple organ dysfunction syndrome) complications Each complication will be graded according to Clavien-Dindo classification. Re-admission or visiting emergency room will be checked and recorded. | within 90 days after operation |
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Inclusion Criteria:
Exclusion Criteria:
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All consecutive patients with clinically documented primary Esophageal or Esophagogastric Junction malignancy (including Siewert I and II) undergoing elective surgery with curative intent - via open, laparoscopic or robotic approach
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| Name | Affiliation | Role |
|---|---|---|
| Andrey Ryabov, MD, PhD | P.Herzen Moscow Oncological Research Institute | Study Director |
| Vladimir Khomyakov, MD, PhD | P.Herzen Moscow Oncological Research Institute | Principal Investigator |
| Nuriddin Abdulkhakimov, MD, PhD | P.Herzen Moscow Oncological Research Institute | Principal Investigator |
| Pavel Smirnov | P.Herzen Moscow Oncological Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| N.Alexandrov National Cancer Centre of Belarus | Minsk | Belarus | ||||
| Bryansk Regional Oncological Hospital |
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|
| Bryansk |
| Russia |
| Cheboksary Republican Clinical Oncology Dispensary | Cheboksary | Russia |
| M.Sigal Republican Medical Oncology Dispensary | Kazan' | Russia |
| A.Loginov Moscow Clinical Scientific Center | Moscow | Russia |
| Moscow City Oncology Hospital № 62 | Moscow | Russia |
| P.Herzen Moscow Oncological Research Institute | Moscow | Russia |
| S.Yudin Moscow Oncological Center No.1 | Moscow | Russia |
| University Clinical Hospital №1 of Sechenov University | Moscow | Russia |
| University Clinical Hospital №4 of Sechenov University | Moscow | Russia |
| Vishnevsky National Medical Research Center of Surgery | Moscow | Russia |
| Nizhny Novgorod Regional Clinical Oncological Dispensary | Nizhny Novgorod | Russia |
| Novosibirsk Regional Clinical Oncology Dispensary | Novosibirsk | Russia |
| A.Tsyb Medical Radiological Research Centre | Obninsk | Russia |
| Rostov-on-Don National Medical Research Centre for Oncology | Rostov-on-Don | Russia |
| Leningrad Regional Clinical Hospital | Saint Petersburg | Russia |
| Saratov Regional Clinical Oncological Dispensary | Saratov | Russia |
| Ufa Republican Clinical Oncology Dispensary | Ufa | Russia |
| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| D017558 | Elective Surgical Procedures |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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