The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal hypersensitivity in adult patients for six months follow-up. patients will be asked to report pain degree on the visual analogue scale (VAS) along the follow up periods on both groups.

Inclusion Criteria:

• Good oral hygiene.
• Cooperative patients who show interest to participate in the study and welling to sign the informed consent.
• Healthy patients with no history of previous systematic diseases that can affect their oral health.
• Normal and healthy gingival tissue.
• Teeth that have no cavitation or restorations.
• Patients with at least 20 natural permanent teeth and at least two teeth with a VAS score from 4 to 10.
• Anterior teeth.

Exclusion Criteria:

• Allergic to the ingredients used in the study.
• Gastrointestinal disorders (They have repeated vomiting attacks).
• Medically compromised (They cannot tolerate the procedures).
• Taking desensitizing treatment in the last 6 months (It affects the outcome).
• Taking anti-inflammatory drugs (It affects the hypersensitivity perception).
• Pregnant females (They complain from nausea and repeated vomiting attacks)
• Smokers (Smoking will affect the oral hygiene and periodontal health).

Participants and both assessors will be blind to the type of material used.