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| Name | Class |
|---|---|
| Consejo General de Colegios Oficiales de EnfermerÃa España | UNKNOWN |
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The general objective of this randomized and longitudinal clinical study was to estimate the frequencies of ApoE variants both in the user population of the "Messengers of Peace" Residences and the "Associations of Relatives of Alzheimer's Patients" in Castile y Leon, since, due to its geographical location at the crossroads, it has received multiple genetic contributions from both northern Europe, the Mediterranean area and northern Africa.
The main questions it aims to answer are:
In the context of Alzheimer disease research, it is widely recognized that the ApoE gene plays a fundamental role in the genetic predisposition of this disease. With three major alleles: ApoE2, ApoE3, and ApoE4, genetic variability in the ApoE gene has been the subject of extensive attention in previous research and its association with increased risk of Alzheimer's disease has remained consistent. Within this framework, three hypotheses are proposed focused on understanding the specific influence of ApoE on Alzheimer's disease and exploring the possible underlying mechanisms.
Within this framework, three hypotheses are proposed focused on understanding the specific influence of ApoE on Alzheimer disease and exploring the possible underlying mechanisms:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group of cases diagnosed with Alzheimer's disease | Active Comparator | Participants: Men and women with age between 60 and 90 years |
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| Control group of healthy individuals without a diagnosis of Alzheimer's disease | Sham Comparator | Participants: Men and women with age between 60 and 90 years |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Kit Buccal swab collection & stabilization de Canvax® | Diagnostic Test | Assessment of ApoE variant in saliva samples as a potential biomarker for Alzheimer's disease. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Distribution of ApoE variants in the Alzheimer's disease population diagnosed in Castile and Leon. | The saliva samples will be processed to purify and extract DNA. Subsequently, a PCR amplification will be performed to check the ApoE alleles and genotypes. | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular factors in individuals with Alzheimer's disease and healthy subjects. | We will analyze whether there are significant differences between individuals with Alzheimer's disease and healthy subjects in terms of cardiovascular risk factors (Diabetes mellitus, cardiac pathology, hypercholesterolemia and high blood pressure) using the z-test for difference in proportions. | 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of León | León | 240071 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28085496 | Background | Alharbi KK, Syed R, Alharbi FK, Khan IA. Association of Apolipoprotein E Polymorphism with Impact on Overweight University Pupils. Genet Test Mol Biomarkers. 2017 Jan;21(1):53-57. doi: 10.1089/gtmb.2016.0190. | |
| 14578332 | Background | Pantelidis P, Lambert-Hammill M, Wierzbicki AS. Simple sequence-specific-primer-PCR method to identify the three main apolipoprotein E haplotypes. Clin Chem. 2003 Nov;49(11):1945-8. doi: 10.1373/clinchem.2003.021683. No abstract available. |
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It is a longitudinal randomised clinical study, in which two study groups were used. A group of cases diagnosed with Alzheimer's disease and a control group of healthy individuals without Alzheimer's disease.
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| Cholesterol levels according to ApoE Genotype | Other | Enhancing the quality of life of study participants by investigating cholesterol levels based on their ApoE genotype. |
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| Assessing cardiovascular risk factors in all participants | Other | Through individual interviews, record cardiovascular factors and assess their correlation with Alzheimer's disease. |
|
| ApoE genotypes and cholesterol levels in the Alzheimer's disease population diagnosed in Castile and Leon. | To assess the presence of significant differences in the mean cholesterol values across different genotypes, an analysis of variance (ANOVA) test will be applied. | 9 months |
| 24502694 | Background | Reales G, Hernandez CL, Dugoujon JM, Novelletto A, Cuesta P, Fortes-Lima C, Rodriguez JN, Calderon R. New insights into the distribution of APOE polymorphism in the Iberian Peninsula. The case of Andalusia (Spain). Ann Hum Biol. 2014 Sep-Oct;41(5):443-52. doi: 10.3109/03014460.2013.877966. Epub 2014 Feb 6. |
| 20734437 | Background | Eisenberg DT, Kuzawa CW, Hayes MG. Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history. Am J Phys Anthropol. 2010 Sep;143(1):100-11. doi: 10.1002/ajpa.21298. |
| 19906263 | Background | Reitz C, Mayeux R. Use of genetic variation as biomarkers for Alzheimer's disease. Ann N Y Acad Sci. 2009 Oct;1180:75-96. doi: 10.1111/j.1749-6632.2009.04945.x. |
| 27470930 | Background | Salameh TS, Rhea EM, Banks WA, Hanson AJ. Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. Exp Biol Med (Maywood). 2016 Sep;241(15):1676-83. doi: 10.1177/1535370216660770. Epub 2016 Jul 28. |
| 33375167 | Background | Gonzalez RD, Gomes I, Gomes C, Rocha R, Duraes L, Sousa P, Figueruelo M, Rodriguez M, Pita C, Hornero R, Gomez C, Lopes AM, Pinto N, Martins S. APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol. Genes (Basel). 2020 Dec 22;12(1):4. doi: 10.3390/genes12010004. |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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