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This study compares the combination of antiplatelets and antihistamine versus antihistamine alone for the treatment of chronic spontaneous urticaria
This study is a randomized control trial comparing the effectiveness of the combination of antiplatelets and antihistamine and antihistamine alone for the treatment of chronic spontaneous urticaria
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Desloratadine | Active Comparator | Oral desloratadine 20 mg/day (antihistamine) for 4 weeks |
|
| Desloratadine plus cilostazol and dipyridamole | Experimental | Oral desloratadine 20 mg/day (antihistamine) in conjunction with cilostazol 150 mg/day and dipyridamole 50 mg/day (antiplatelets) for 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Desloratadine plus cilostazol and dipyridamole | Drug | Desloratadine 20 mg/day plus cilostazol 150 mg/day and dipyridamole 50 mg/day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Weekly urticaria activity score | Urticaria activity score over 7 days (UAS7): scores 0-42 from mild to severe | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| D-dimer levels | D-dimer levels | 4 weeks |
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Inclusion Criteria:
Chronic spontaneous urticaria
D-dimer levels over 500 ng/ml
Not respond to a conventional dose of antihistamine
Exclusion Criteria:
Are taking aspirin
Have bleeding tendency
Have concurrent severe medical illnesses
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| Name | Affiliation | Role |
|---|---|---|
| Jettanong Klaewsongkram, MD | Chulalongkorn University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Chulalongkorn University | Bangkok | 10330 | Thailand |
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| ID | Term |
|---|---|
| D000080223 | Chronic Urticaria |
| ID | Term |
|---|---|
| D014581 | Urticaria |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C121345 | desloratadine |
| D000077407 | Cilostazol |
| D004176 | Dipyridamole |
| D006633 | Histamine Antagonists |
| ID | Term |
|---|---|
| D013777 | Tetrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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Patients diagnosed with chronic urticaria will be assigned to 2 treatment arms. 1. high dose antihistamine with antiplatelets; and 2. high dose antihistamine alone.
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Identical capsules
|
| Desloratadine | Drug | Desloratadine 20 mg/day |
|
|
| D006969 |
| Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011804 |
| Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D011743 | Pyrimidines |
| D018494 | Histamine Agents |
| D018377 | Neurotransmitter Agents |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D045505 | Physiological Effects of Drugs |