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Dye- spray chromoendoscopy remains the recommended gold standard approach for IBD dysplasia surveillance colonoscopy however recently published European and American guidelines recommend either dye-spray or virtual chromoendoscopy can be used for surveillance. The newer Imaged Enhanced Endoscopy technologies TXI and LCI have not formally been evaluated in IBD surveillance in a randomised controlled trial setting. These modes can easily be applied during colonoscopy and if demonstrated to be effective may save time and eliminate the need for dye-spray chromoendoscopy in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dye Spray Chromoendoscopy | Placebo Comparator | Patients undergoing surveillance with dye spray chromoendoscopy |
|
| TXI | Active Comparator | Patients undergoing surveillance with TXI (Texture and Colour Enhancement Imaging) |
|
| LCI | Active Comparator | Patients undergoing surveillance with LCI (Linked Colour Imaging ) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Image Enhanced Endoscopy Filters | Procedure | Patients that undergoing surveillance and consent to be involved in the study will be randomised to undergo surveillance with LCI, TXI or dye-spray chromoendoscopy (methylene blue). |
| Measure | Description | Time Frame |
|---|---|---|
| Dysplasia Detection Rate | Overall Dysplasia Detection rate | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Withdrawal times | Withdrawal time for procedure | 2 years |
| Characterisation of lesions | Accurate characterisation compared to histology |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sherman Picardo, MBBS (hon), MSc | Contact | 0892242244 | sherman.picardo@health.wa.gov.au |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royal Perth Hosptial | Recruiting | Perth | Western Australia | 6000 | Australia |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| 2 years |