The aims of this prospective multicentric study is to determine the types of enteroviruses (EVs) responsible for hand, foot and mouth disease (HFMD) or herpangina in children seen within an ambulatory setting :

• to detect an EV-A71 epidemic or another type associated with atypical forms of the disease at an early stage
• to describe and compare the epidemiological, demographic, clinical and virological characteristics of these infections between the different types of EV.

Any child presenting signs suggestive of HFMD/Herpangina can be included in the study by one of the investigating paediatricians. After giving the information note to the parents (and to children over 3 years of age) and asking them not to object, the paediatrician collects a throat or mouth swab to confirm the enterovirus infection. At the same time as the swab is taken, anonymised demographic and clinical data are collected by the doctor during the consultation. The sample and the information sheet are sent to the National Reference Laboratory for enteroviruses (Clermont-Ferrand University Hospital).The diagnosis is performed by EV genome detection and if positive, genotyping is done to identify the type of the enteroviruses.

Inclusion Criteria:

• Children aged 0 to 10 years presenting with HFMD or herpangina

Exclusion Criteria:

• Refusal to participate by holders of parental authority
• Refusal to participate for children over 3 years of age

Children aged between 0 and 10 years seen for HFMD/Herpangina by one of the paediatric investigators.

HFMD is defined by the presence of at least two of the following clinical signs:

• a vesicular or non-vesicular rash on :

  • the palms of the hands
  • soles of the feet, or the buttocks
  • knees or elbows,
  • mouth or perioral ulcers,

• vesicular or non-generalized eruption.

Herpangina is defined by the presence of oral ulcers located mainly in the posterior part of the oral cavity: palate, uvula.