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Serum vitamin D levels in drug-induced non-immediate reactions
The study of serum vitamin D levels in patients presented with drug-induced non-immediate cutaneous adverse reactions compared to those in drug-tolerant control subjects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1. Patients diagnosed with drug-induced severe non-immediate cutaneous reactions | Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptom (DRESS), acute generalized exanthematous pustulosis (AGEP) | ||
| 2. Patients diagnosed with drug-induced non-severe non-immediate cutaneous reactions | Maculopapular exanthem (MPE), fixed drug eruption (FDE) | ||
| 3. Subjects who tolerated drugs potentially causing severe non-immediate cutaneous reactions | Studied drug groups matched patients in group 1 | ||
| 4. Subjects who tolerated drugs potentially causing non-severe non-immediate cutaneous reactions | Studied drug groups matched patients in group 2 |
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| Measure | Description | Time Frame |
|---|---|---|
| Serum vitamin D levels | Serum vitamin D levels at baseline | At baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Cases: Subjects who develop drug-induced non-immediate cutaneous reactions
Controls: subjects who can tolerate similar drug groups without allergic reactions
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| Name | Affiliation | Role |
|---|---|---|
| Jettanong klaewsongkram, MD | Chulalongkorn University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Chulalongkorn University | Bangkok | 10330 | Thailand |
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| ID | Term |
|---|---|
| D013262 | Stevens-Johnson Syndrome |
| D063926 | Drug Hypersensitivity Syndrome |
| D003875 | Drug Eruptions |
| D014808 | Vitamin D Deficiency |
| D004342 | Drug Hypersensitivity |
| ID | Term |
|---|---|
| D013280 | Stomatitis |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D003872 | Dermatitis |
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| D012871 |
| Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D004892 | Erythema Multiforme |
| D004890 | Erythema |
| D012872 | Skin Diseases, Vesiculobullous |
| D006968 | Hypersensitivity, Delayed |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D064420 | Drug-Related Side Effects and Adverse Reactions |
| D064419 | Chemically-Induced Disorders |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |