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| ID | Type | Description | Link |
|---|---|---|---|
| 8K12AR084222-15 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | NIH |
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The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
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| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Measured in millimeters of mercury (mmHg). | Baseline |
| Arterial stiffness | Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec) | Baseline |
| Endothelial function | Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Sympathetic nerve burst frequency | Measured by Microneurography reported as number of nerve bursts per minute (burst/min) | Baseline |
| Sympathetic nerve burst incidence | Measured by Microneurography reported as number of nerve burst per 100 heart beats (burst/100 heart beats) |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral autoregulation | Measured by transcranial doppler ultrasound (cm/sec). | Baseline |
| Sympathetic action potentials per burst | Measured by Microneurography reported as action potentials per burst (reflecting firing rate). |
Inclusion Criteria:
Exclusion Criteria:
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Subjects with or without untreated obstructive sleep apnea will be recruited from Mayo Clinic in Rochester, MN.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joshua Bock, PhD | Contact | (507) 422-0768 | Bock.Joshua@mayo.edu | |
| Ian Greenlund, PhD | Contact | (507) 422-3411 | Greenlund.Ian@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Joshua Bock, PhD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Recruiting | Rochester | Minnesota | 55905 | United States |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| Baseline |
| Sympathetic nerve burst amplitude (AU) | Measured by Microneurography reported in arbitrary units (AU) | Baseline |
| Total muscle sympathetic nerve activity (MSNA) | Measured by Microneurography reported burst arbitrary units per minute (AU/min) | Baseline |
| Baseline |
| Sympathetic action potential clusters per burst | Measured by Microneurography reported as clusters per burst (reflecting recruitment of latent subpopulations). | Baseline |
| Sympathetic action potential conduction latency of each cluster | Measured by Microneurography reported as conduction latency of each cluster (reflecting synaptic delays and verifying larger amplitude clusters as new populations). | Baseline |
| Immune function | Immune function will be measured as percent of parent cell population. | Baseline |
| Urinary Extracellular Vesicle Presence and Content | Number of extracellular vesicles present in a 24 hour urine collection and the contents being carried by those vesicles. | Baseline |
| Plasma Extracellular Vesicle Presence and Content | Number of extracellular vesicles present in blood plasma sample and the contents being carried by those vesicles. | Baseline |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |