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This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis Group | Experimental | Participants in this group will self-administer their own flower cannabis product (that they purchased for use in the study from a legal-market dispensary) ad libitum inside their homes. Researchers will not handle the product or instruct participants on how much to use during the session. |
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| Alcohol Group | Experimental | Participants in this group will be administered a dose of alcohol by researchers in our mobile lab. The dose is designed (based on participant sex and body weight) to bring blood alcohol concentration to .06 g/dL. |
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| Alcohol + Cannabis Group | Experimental | Participants in this group will first self-administer their own flower cannabis product (that they purchased for use in the study from a legal-market dispensary) ad libitum inside their homes. Researchers will not handle the product or instruct participants on how much to use during the session. They will then return to the mobile lab which will be parked outside their residence and will be administered a dose of alcohol by researchers. The dose is designed (based on participant sex and body weight) to bring blood alcohol concentration to .06 g/dL. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol | Other | Participants in this condition will receive the standard alcohol dose |
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| Measure | Description | Time Frame |
|---|---|---|
| Electroencephalography (EEG) Objective Cognitive Function Measures--Amplitude (microvolts) | The EEG amplitude (measured in microvolts) will be obtained while participants perform the speeded visual flanker task | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Electroencephalography (EEG) Objective Cognitive Function Measures--Latency (milliseconds) | The EEG latency (measured in milliseconds) will be obtained while participants perform the speeded visual flanker task | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Standing postural stability | An iPod Touch will be attached to each participant's hip with a simple elastic/Velcro strap. An app on the device will record fine grained movements while they try to stand as still as possible for 30-60 seconds under four conditions that vary in terms of demand on the proprioceptive system (eyes open, eyes closed), and on a stable vs. soft (foam) surface. | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
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| Measure | Description | Time Frame |
|---|---|---|
| Breath Alcohol Concentration | Measured using hand-held breathalyzer device | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Blood Delta-9-tetrahydrocannabinol (THC) Levels |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hollis C Karoly, PhD | Contact | 970-491-3677 | hollis.karoly@colostate.edu | |
| Patricia Davies, PhD | Contact | (970) 491-7294 | patricia.davies@colostate.edu |
| Name | Affiliation | Role |
|---|---|---|
| Hollis Karoly, PhD | Colorado State University | Principal Investigator |
| Patricia Davies, PhD | Colorado State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Colorado State University | Recruiting | Fort Collins | Colorado | 80523 | United States |
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| C587251 | nabiximols |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Cannabis | Other | Participants in this group will self-administer legal-market flower cannabis |
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THC measured from blood samples
| Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Blood Cannabidiol (CBD) Levels | CBD measured from blood samples | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Blood Levels of 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) | THC-COOH measured from blood samples | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |
| Blood Levels of 11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) | 11-OH-THC measured from blood samples | Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use |